Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Oct 25;91(22):10243–10246. doi: 10.1073/pnas.91.22.10243

The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

R M Harland 1
PMCID: PMC44995  PMID: 7937933

Full text

PDF
10243

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amaya E., Musci T. J., Kirschner M. W. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell. 1991 Jul 26;66(2):257–270. doi: 10.1016/0092-8674(91)90616-7. [DOI] [PubMed] [Google Scholar]
  2. Amaya E., Stein P. A., Musci T. J., Kirschner M. W. FGF signalling in the early specification of mesoderm in Xenopus. Development. 1993 Jun;118(2):477–487. doi: 10.1242/dev.118.2.477. [DOI] [PubMed] [Google Scholar]
  3. Baarends W. M., van Helmond M. J., Post M., van der Schoot P. J., Hoogerbrugge J. W., de Winter J. P., Uilenbroek J. T., Karels B., Wilming L. G., Meijers J. H. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct. Development. 1994 Jan;120(1):189–197. doi: 10.1242/dev.120.1.189. [DOI] [PubMed] [Google Scholar]
  4. Bolce M. E., Hemmati-Brivanlou A., Kushner P. D., Harland R. M. Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin. Development. 1992 Jul;115(3):681–688. doi: 10.1242/dev.115.3.681. [DOI] [PubMed] [Google Scholar]
  5. Brummel T. J., Twombly V., Marqués G., Wrana J. L., Newfeld S. J., Attisano L., Massagué J., O'Connor M. B., Gelbart W. M. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell. 1994 Jul 29;78(2):251–261. doi: 10.1016/0092-8674(94)90295-x. [DOI] [PubMed] [Google Scholar]
  6. Christian J. L., McMahon J. A., McMahon A. P., Moon R. T. Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development. 1991 Apr;111(4):1045–1055. doi: 10.1242/dev.111.4.1045. [DOI] [PubMed] [Google Scholar]
  7. Christian J. L., Moon R. T. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. Genes Dev. 1993 Jan;7(1):13–28. doi: 10.1101/gad.7.1.13. [DOI] [PubMed] [Google Scholar]
  8. Christian J. L., Olson D. J., Moon R. T. Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm. EMBO J. 1992 Jan;11(1):33–41. doi: 10.1002/j.1460-2075.1992.tb05024.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cooke J., Smith J. C. The midblastula cell cycle transition and the character of mesoderm in u.v.-induced nonaxial Xenopus development. Development. 1987 Feb;99(2):197–210. doi: 10.1242/dev.99.2.197. [DOI] [PubMed] [Google Scholar]
  10. Cornell R. A., Kimelman D. Activin-mediated mesoderm induction requires FGF. Development. 1994 Feb;120(2):453–462. doi: 10.1242/dev.120.2.453. [DOI] [PubMed] [Google Scholar]
  11. Dale L., Howes G., Price B. M., Smith J. C. Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development. 1992 Jun;115(2):573–585. doi: 10.1242/dev.115.2.573. [DOI] [PubMed] [Google Scholar]
  12. Dale L., Slack J. M. Regional specification within the mesoderm of early embryos of Xenopus laevis. Development. 1987 Jun;100(2):279–295. doi: 10.1242/dev.100.2.279. [DOI] [PubMed] [Google Scholar]
  13. Estevez M., Attisano L., Wrana J. L., Albert P. S., Massagué J., Riddle D. L. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 1993 Oct 14;365(6447):644–649. doi: 10.1038/365644a0. [DOI] [PubMed] [Google Scholar]
  14. Georgi L. L., Albert P. S., Riddle D. L. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell. 1990 May 18;61(4):635–645. doi: 10.1016/0092-8674(90)90475-t. [DOI] [PubMed] [Google Scholar]
  15. Gerhart J., Danilchik M., Doniach T., Roberts S., Rowning B., Stewart R. Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development. Development. 1989;107 (Suppl):37–51. doi: 10.1242/dev.107.Supplement.37. [DOI] [PubMed] [Google Scholar]
  16. Gimlich R. L., Cooke J. Cell lineage and the induction of second nervous systems in amphibian development. Nature. 1983 Dec 1;306(5942):471–473. doi: 10.1038/306471a0. [DOI] [PubMed] [Google Scholar]
  17. Green J. B., New H. V., Smith J. C. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell. 1992 Nov 27;71(5):731–739. doi: 10.1016/0092-8674(92)90550-v. [DOI] [PubMed] [Google Scholar]
  18. Green J. B., Smith J. C., Gerhart J. C. Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern. Development. 1994 Aug;120(8):2271–2278. doi: 10.1242/dev.120.8.2271. [DOI] [PubMed] [Google Scholar]
  19. He W. W., Gustafson M. L., Hirobe S., Donahoe P. K. Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family. Dev Dyn. 1993 Feb;196(2):133–142. doi: 10.1002/aja.1001960207. [DOI] [PubMed] [Google Scholar]
  20. Hemmati-Brivanlou A., Kelly O. G., Melton D. A. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 1994 Apr 22;77(2):283–295. doi: 10.1016/0092-8674(94)90320-4. [DOI] [PubMed] [Google Scholar]
  21. Hemmati-Brivanlou A., Melton D. A. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 1992 Oct 15;359(6396):609–614. doi: 10.1038/359609a0. [DOI] [PubMed] [Google Scholar]
  22. Hemmati-Brivanlou A., Melton D. A. Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell. 1994 Apr 22;77(2):273–281. doi: 10.1016/0092-8674(94)90319-0. [DOI] [PubMed] [Google Scholar]
  23. Jones C. M., Lyons K. M., Lapan P. M., Wright C. V., Hogan B. L. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. 1992 Jun;115(2):639–647. doi: 10.1242/dev.115.2.639. [DOI] [PubMed] [Google Scholar]
  24. Kato K., Gurdon J. B. An inhibitory effect of Xenopus gastrula ectoderm on muscle cell differentiation and its role for dorsoventral patterning of mesoderm. Dev Biol. 1994 May;163(1):222–229. doi: 10.1006/dbio.1994.1138. [DOI] [PubMed] [Google Scholar]
  25. Koenig B. B., Cook J. S., Wolsing D. H., Ting J., Tiesman J. P., Correa P. E., Olson C. A., Pecquet A. L., Ventura F., Grant R. A. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol. 1994 Sep;14(9):5961–5974. doi: 10.1128/mcb.14.9.5961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Köster M., Plessow S., Clement J. H., Lorenz A., Tiedemann H., Knöchel W. Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity. Mech Dev. 1991 Mar;33(3):191–199. doi: 10.1016/0925-4773(91)90027-4. [DOI] [PubMed] [Google Scholar]
  27. LaBonne C., Whitman M. Mesoderm induction by activin requires FGF-mediated intracellular signals. Development. 1994 Feb;120(2):463–472. doi: 10.1242/dev.120.2.463. [DOI] [PubMed] [Google Scholar]
  28. Lin H. Y., Wang X. F., Ng-Eaton E., Weinberg R. A., Lodish H. F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell. 1992 Feb 21;68(4):775–785. doi: 10.1016/0092-8674(92)90152-3. [DOI] [PubMed] [Google Scholar]
  29. Mathews L. S., Vale W. W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 1991 Jun 14;65(6):973–982. doi: 10.1016/0092-8674(91)90549-e. [DOI] [PubMed] [Google Scholar]
  30. Maéno M., Ong R. C., Xue Y., Nishimatsu S., Ueno N., Kung H. F. Regulation of primary erythropoiesis in the ventral mesoderm of Xenopus gastrula embryo: evidence for the expression of a stimulatory factor(s) in animal pole tissue. Dev Biol. 1994 Feb;161(2):522–529. doi: 10.1006/dbio.1994.1050. [DOI] [PubMed] [Google Scholar]
  31. Penton A., Chen Y., Staehling-Hampton K., Wrana J. L., Attisano L., Szidonya J., Cassill J. A., Massagué J., Hoffmann F. M. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 1994 Jul 29;78(2):239–250. doi: 10.1016/0092-8674(94)90294-1. [DOI] [PubMed] [Google Scholar]
  32. Ruiz i Altaba A., Jessell T. Retinoic acid modifies mesodermal patterning in early Xenopus embryos. Genes Dev. 1991 Feb;5(2):175–187. doi: 10.1101/gad.5.2.175. [DOI] [PubMed] [Google Scholar]
  33. Schulte-Merker S., Smith J. C., Dale L. Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction? EMBO J. 1994 Aug 1;13(15):3533–3541. doi: 10.1002/j.1460-2075.1994.tb06660.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Slack J. M. Inducing factors in Xenopus early embryos. Curr Biol. 1994 Feb 1;4(2):116–126. doi: 10.1016/s0960-9822(94)00027-8. [DOI] [PubMed] [Google Scholar]
  35. Smith J. C., Slack J. M. Dorsalization and neural induction: properties of the organizer in Xenopus laevis. J Embryol Exp Morphol. 1983 Dec;78:299–317. [PubMed] [Google Scholar]
  36. Smith W. C., Harland R. M. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell. 1992 Sep 4;70(5):829–840. doi: 10.1016/0092-8674(92)90316-5. [DOI] [PubMed] [Google Scholar]
  37. Smith W. C., Harland R. M. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell. 1991 Nov 15;67(4):753–765. doi: 10.1016/0092-8674(91)90070-f. [DOI] [PubMed] [Google Scholar]
  38. Smith W. C., Knecht A. K., Wu M., Harland R. M. Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature. 1993 Feb 11;361(6412):547–549. doi: 10.1038/361547a0. [DOI] [PubMed] [Google Scholar]
  39. Sokol S. Y., Melton D. A. Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Dev Biol. 1992 Dec;154(2):348–355. doi: 10.1016/0012-1606(92)90073-p. [DOI] [PubMed] [Google Scholar]
  40. Sokol S., Melton D. A. Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature. 1991 May 30;351(6325):409–411. doi: 10.1038/351409a0. [DOI] [PubMed] [Google Scholar]
  41. Stewart R. M., Gerhart J. C. The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula. Development. 1990 Jun;109(2):363–372. doi: 10.1242/dev.109.2.363. [DOI] [PubMed] [Google Scholar]
  42. Thomsen G. H., Melton D. A. Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell. 1993 Aug 13;74(3):433–441. doi: 10.1016/0092-8674(93)80045-g. [DOI] [PubMed] [Google Scholar]
  43. Wittbrodt J., Rosa F. M. Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin. Genes Dev. 1994 Jun 15;8(12):1448–1462. doi: 10.1101/gad.8.12.1448. [DOI] [PubMed] [Google Scholar]
  44. Wrana J. L., Attisano L., Wieser R., Ventura F., Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 1994 Aug 4;370(6488):341–347. doi: 10.1038/370341a0. [DOI] [PubMed] [Google Scholar]
  45. ten Dijke P., Ichijo H., Franzén P., Schulz P., Saras J., Toyoshima H., Heldin C. H., Miyazono K. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene. 1993 Oct;8(10):2879–2887. [PubMed] [Google Scholar]
  46. ten Dijke P., Yamashita H., Sampath T. K., Reddi A. H., Estevez M., Riddle D. L., Ichijo H., Heldin C. H., Miyazono K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem. 1994 Jun 24;269(25):16985–16988. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES