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Binding of alternate substrate, DHN (6). (A) Electron density map of NcsB1/SAH/6 active site, generated without 6. 2Fo – Fc map (blue, 1.5 σ) and Fo – Fc map (green, 3 σ) (B) Overlay of 2 and 6 in NcsB1 active site. Naphthoic acid 6 is hydrogen-bonded to Arg11 via a water and the 4-hydroxyl group is in sufficiently close proximity to SAM (2.1 Å, SAM from NcsB1/SAM/2 structure) for methyl transfer to occur.
