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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Epigenomics. 2015;7(3):413–425. doi: 10.2217/epi.15.8

Figure 1. Mouse prostate development and localization of Dnmt1 expression over time.

Figure 1

In mouse the prostate develops from the urogenital sinus (UGS). Prostate specification begins at 14 days post coitus after which time epithelial prostate buds (red) begin to emerge and elongate (16–18 dpc) into surrounding mesenchyme (grey). Prostate buds then undergo branching morphogenesis, which continues postnatally. Insets represent magnified images of prostate epithelial and mesenchymal morphology over the course of bud formation. Dnmt1 mRNA expression patterns are shown in purple displaying widespread expression in mesenchyme prior to bud formation before diminishing in mesenchyme and localizing to developing prostate buds and bud tips.

For color images please see online at: www.futuremedicine.com/doi/full/10.2217/EPI.15.8.