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. 1994 Oct 25;91(22):10502–10506. doi: 10.1073/pnas.91.22.10502

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

I Ingelbrecht 1, H Van Houdt 1, M Van Montagu 1, A Depicker 1
PMCID: PMC45049  PMID: 7937983

Abstract

Endogenous plant genes or transgenes can be silenced on introduction of homologous gene sequences. Here we document a reporter gene-silencing event in Nicotiana tabacum that has a distinctive combination of features--i.e., (i) silencing occurs by a posttranscriptional process, (ii) silencing correlates with DNA methylation, and (iii) this de novo methylation is not restricted to cytosines located in the symmetrical motifs CG and CXG.

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Selected References

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