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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Pain. 2015 Apr;156(0 1):S2–10. doi: 10.1097/01.j.pain.0000460345.92588.4b

Figure 3. Lipid kinases (in blue) that regulate levels of PIP2 (PI(4,5)P2) could affect nociceptive sensitization when inhibited or genetically deleted.

Figure 3

PIP2 levels decrease significantly via inhibition of PIP5K and modestly when PI4K is inhibited[59]. Whether PIKfyve and PIP4K contribute to PIP2 levels in DRG neurons is unknown. PI3K inhibition leads to significant attenuation of NGF-induced TRPV1 sensitization. DGK phosphorylation of DAG produces PA, which has been implicated in PIP5K activation, suggesting a feedforward mechanism for PIP2 signaling.