Table 5.

Cox Proportional hazards regression model demonstrating that reaching the initial target trough in <5 days is associated with improved study outcome measures

Outcome	Hazard Ratio (95% CI)	P value
Inpatient length of staya
Time to target trough
<5 vs. ≥5 days	2.52 (1.54–4.14)	<0.001
1–<2 vs. ≥5 days	1.97 (1.09–3.56)	0.024
2–<3 vs. ≥5 days	2.3 (1.35–3.92)	0.002
3–<4 vs. ≥5 days	2.13 (1.27–3.56)	0.004
Time to clinical stabilitya
Time to target trough
<5 vs. ≥5 days	2.13 (1.16–3.93)	0.015
1–<2 vs. ≥5 days	1.51 (0.75–3.04)	0.243
2–<3 vs. ≥5 days	1.09 (0.56–2.13)	0.791
3–<4 vs. ≥5 days	1.41 (0.76–2.62)	0.276
Inpatient length of VAN treatmenta
Time to target trough
<5 days vs. ≥5 days	2.95 (1.8–4.82)	<0.001
1–<2 vs. ≥5 days	3.44 (1.86–6.35)	<0.001
2– < 3 vs. ≥5 days	2.18 (1.27–3.74)	0.005
3– < 4 vs. ≥5 days	4.67 (2.68–8.14)	<0.001
Time to normal white blood cell counta
Time to target trough:
<5 days vs. ≥5 days	2.08 (1.06–4.08)	0.034
1–<2 vs. ≥5 days	2.12 (0.86–5.21)	0.1
2–<3 vs. ≥5 days	1.26 (0.57–2.77)	0.565
3–<4 vs. ≥5 days	1.72 (0.84–3.53)	0.138

^aAnalysis restricted to those who reached target trough.