Table 1.

Biological MMP inhibitory potency and selectivity profile

Inhibitor	MMP-13[a]	MMP-1, -2, -3, -7, -8, -9, -12, -14[b]
2	5.13 μm [pIC50=5.29±0.17]	<50 % inhibition at 20 μm
3	10.90 nm [pIC50=7.96±0.05]	<50 % inhibition at 20 μm
4	5.78 nm [pIC50=8.24±0.15]	<50 % inhibition at 10 μm

[a] Data represent the mean ±SD of one experiment performed in triplicate. [b] Single-dose inhibition data are from one experiment performed in triplicate; confidence intervals, detailed single-dose inhibition data, and full experimental details for the biological assays are given in the Supporting Information.