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European Heart Journal logoLink to European Heart Journal
. 2015 May 14;36(28):1805–1811. doi: 10.1093/eurheartj/ehv177

Uninterrupted rivaroxaban vs. uninterrupted vitamin K antagonists for catheter ablation in non-valvular atrial fibrillation

Riccardo Cappato 1,2, Francis E Marchlinski 3, Stefan H Hohnloser 4, Gerald V Naccarelli 5, Jim Xiang 6, David J Wilber 7, Chang-Sheng Ma 8, Susanne Hess 9, Darryl S Wells 10, George Juang 11, Johan Vijgen 12, Burkhard J Hügl 13, Richard Balasubramaniam 14, Christian De Chillou 15, D Wyn Davies 16, L Eugene Fields 17, Andrea Natale 18,*, on behalf of the VENTURE-AF Investigators
PMCID: PMC4508487  PMID: 25975659

Abstract

Aims

VENTURE-AF is the first prospective randomized trial of uninterrupted rivaroxaban and vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (NVAF) undergoing catheter ablation (CA).

Methods and results

Trial size was administratively set at 250, the protocol-specified target. Events were independently and blindly adjudicated. We randomly assigned 248 NVAF patients to uninterrupted rivaroxaban (20 mg once-daily) or to an uninterrupted VKA prior to CA and for 4 weeks afterwards. The primary endpoint was major bleeding events after CA. Secondary endpoints included thromboembolic events (composite of stroke, systemic embolism, myocardial infarction, and vascular death) and other bleeding or procedure-attributable events. Patients were 59.5 ± 10 years of age, 71% male, 74% paroxysmal AF, and had a CHA2DS2-VASc score of 1.6. The average total heparin dose used to manage activated clotting time (ACT) was slightly higher (13 871 vs. 10 964 units; P < 0.001) and the mean ACT level attained slightly lower (302 vs. 332 s; P < 0.001) in rivaroxaban and VKA arms, respectively. The incidence of major bleeding was low (0.4%; 1 major bleeding event). Similarly, thromboembolic events were low (0.8%; 1 ischemic stroke and 1 vascular death). All events occurred in the VKA arm and all after CA. The number of any adjudicated events (26 vs. 25), any bleeding events (21 vs. 18), and any other procedure-attributable events (5 vs. 5) were similar.

Conclusion

In patients undergoing CA for AF, the use of uninterrupted oral rivaroxaban was feasible and event rates were similar to those for uninterrupted VKA therapy.

Name of the Trial Registry

Clinicaltrials.gov trial registration number is NCT01729871.

Keywords: Atrial fibrillation, Catheter ablation, Oral anticoagulant, Uninterrupted, Thromboembolism

Introduction

Catheter ablation (CA) of atrial fibrillation (AF) was first reported in 1996.1 It is now used routinely to establish rhythm control in selected patients.2 The traditional anticoagulation approach is to interrupt administration of an oral vitamin K antagonist (VKA) and use heparin bridging. Recent reports indicate that uninterrupted anticoagulation may be safer and more effective.37 The incidence of major bleeding or thromboembolic events after CA in AF patients randomly assigned to uninterrupted VKA could be as low as 0.38 and 0.25%, respectively.3 Atrial fibrillation guidelines recommend consideration of uninterrupted oral anticoagulation for patients undergoing CA. In a European Heart Rhythm Association survey, 71.6% of respondents reported using the uninterrupted VKA strategy for CA.8

Rivaroxaban is a selective oral direct factor Xa inhibitor anticoagulant approved for multiple clinical indications, including stroke risk reduction in patients with non-valvular AF (NVAF).9,10 Non-randomized studies suggest that it may be feasible to manage patients undergoing CA with rivaroxaban.11 Calls for randomized trials make this study clinically relevant.1214 The objective of this prospective randomized study (NCT01729871) was to determine whether the number of complications associated with uninterrupted rivaroxaban are similar to those for a VKA in this setting.

Methods

The VENTURE-AF (ActiVe-controlled multi-cENTer stUdy with blind-adjudication designed to evaluate the safety of uninterrupted Rivaroxaban and uninterrupted vitamin K antagonists in subjects undergoing cathEter ablation for non-valvular Atrial Fibrillation) trial was a multinational, randomized, open-label, parallel-group phase IIIb study of patients with AF undergoing catheter-based ablation of the arrhythmia substrate. Details of the study design have been published.15 Patients scheduled for CA of AF were randomly assigned 1:1 to rivaroxaban 20 mg orally once-daily (recommended evening dosing) or to VKA [recommended international normalized ratio (INR) of 2.0–3.0].

Study population

Patients aged 18 years or older scheduled for CA of paroxysmal, persistent, or long-standing persistent NVAF were eligible. Exclusion criteria included valvular AF, defined as the presence of a prosthetic heart valve (annuloplasty with or without prosthetic ring, commissurotomy and/or valvuloplasty were permitted), haemodynamically significant mitral valve stenosis or rheumatic heart disease. This trial complied with the Declaration of Helsinki, locally or centrally appointed ethics committees approved the research protocol and informed consent was obtained from the patients (or their guardians/caregivers).

Ablation

Prior to CA, patients randomized to rivaroxaban received a once-daily dose of 20 mg orally, preferentially with the evening meal. Patients randomized to VKA received a VKA regimen based on local standards of care (recommended INR 2.0–3.0). Patients were required to receive continuous oral anticoagulation for at least 3 weeks prior to ablation (delayed CA strategy) or for 1 to 7 days (early CA strategy) if an immediate transoesophageal echocardiography (TOE) or intracardiac echocardiography (ICE) demonstrated the absence of an intra-cardiac thrombus. During CA, patients received intravenous unfractionated heparin to achieve a target activated clotting time (ACT) of 300 to 400 s. After CA, the next post-ablation rivaroxaban dose was administered at least 6 h following establishing haemostasis. The next dose of VKA was administered in accordance with the usual care. After CA, the administration of study drug was continued for 30 ± 5 days after CA and the subsequent anticoagulation regimen was determined by the patient's clinician.

Medications and procedures

The study protocol included recommendations with respect to the general management of rivaroxaban patients, anticoagulant transitions, and reversal strategies for patients with bleeding complications. Rivaroxaban non-compliance was defined by pill count as unexplained missed doses that resulted in the subject returning more than 20% of the prescribed study drug. Interruption and subsequent restarting of VKA was done in accordance with the usual care. This trial did not control for ablation catheter type, ablation parameters, or lesion sets.

Study endpoints

The invasiveness of CA and the expectation of higher rates of bleeding complications compared with thromboembolic events was the basis for the focus on bleeding events in this study. The primary endpoint was the incidence of major bleeding events in the uninterrupted rivaroxaban and uninterrupted VKA treatment groups within the first 30 ± 5 days after CA. Major secondary endpoints included the composite (and individual) events of ischemic stroke, non-central nervous system (CNS) systemic embolism, myocardial infarction (MI), and vascular death; other bleeding events; and procedure-attributable adverse events.

An adjudicated major bleeding event was based on the presence of at least one of the three following definitions: an International Society on Thrombosis and Haemostasis (ISTH) major bleed, a Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) severe/life-threatening bleed or a Thrombosis in Myocardial Infarction (TIMI) major bleed (see Appendix for detail).16,17

The mean rivaroxaban plasma concentration was extrapolated from chromogenic anti-factor Xa assay-based data, collected on the morning of the day of CA.18 The blood sample was drawn on the day of the procedure and the assay performed at a later time.

Study governance

An independent academic Steering Committee oversaw study design and conduct. Inclusion of SC members who were not performing uninterrupted CA was deemed important to ensure diversity of perspective in study design, conduct and evaluation. An independent academic Clinical Endpoint Committee (CEC) performed blinded-adjudication and classification of events. A Writing Committee drafted the initial version of the manuscript. Data management and statistical analyses complied with good clinical practice standards. All authors had full access to data.

Statistical analysis

After traditional estimation of sample size indicated an unfeasibly large number of patients needed to show a significant difference between two randomized (1:1) arms for either establishing non-inferiority or superiority, we decided that a descriptive comparison using ∼250 patients would generate clinically relevant information. We also assumed that ∼20% of patients would be discontinued from the study before undergoing CA. To minimize potentially confounding factors such as enrollment bias, a central randomization strategy was implemented. Patients receive the study drug based on a computer-generated randomization schedule, using randomly permuted blocks and stratification by country.

The intention-to-treat (ITT) analysis set included all randomized patients who met inclusion and exclusion criteria. The per-protocol analysis set was the pre-specified primary analysis set, including all randomized patients who took at least 1 dose of study drug (safety population) and underwent CA. The safety population was used for the primary safety analysis. The treatment-emergent period spanned the time from administration of the first dose until the last dose of study medication plus 2 days. Statistical analyses were descriptive. All continuous variables were expressed in terms of mean or median and standard deviations. Categorical data were expressed as numbers and percentages. Categorical group comparisons were made using the χ2-test without continuity correction. Two-sided probability values of <0.05 were considered to be statistically significant. The SAS FREQ procedure was used for confidence interval calculation. All analyses were performed using SAS 9.2 (SAS Institute, Inc., Cary, NC, USA).

Results

Patient characteristics

A total of 291 adult patients with paroxysmal, persistent, or long-standing persistent NVAF scheduled for elective CA at 46 sites opened for enrollment in five countries (Belgium, France, Germany, the UK, and the USA) were screened between February 2013 and September 2014. Of them, 248 were randomized at 37 sites (ITT population; mean of 6 patients per site), 244 received at least one dose of the assigned study drug (safety population), 221 also underwent CA (per-protocol population), 213 patients completed the study, and no patient was lost to follow-up (Figure 1).

Figure 1.

Figure 1

Patient disposition during the study.

Baseline characteristics were not significantly different between the two treatment groups (Table 1). The mean age was 59.6 ± 10.2 (SD) years. The majority of patients were male, Caucasian and non-Hispanic/Latino, and had paroxysmal AF (73.4%). The mean CHA2DS2-VASc score was 1.6 ± 1.3 and 40.7% of patients had a history of having had at least 1 prior electrical cardioversion procedure and 8.9% had a history of at least 1 prior CA procedure. Approximately 50% of patients were already taking rivaroxaban (21.0%) or a VKA (29.4%) prior to randomization.

Table 1.

Baseline demographic characteristics of the ITT population

Rivaroxaban (N = 124) VKA (N = 124) Total (N = 248) P Value
Mean age, years (SD) 58.6 (9.9) 60.5 (10.5) 59.6 (10.2) 0.211
Age ≥75, n (%) 5 (4.0) 10 (8.1) 15 (6.0) 0.183
Age 65–75 34 (27.4) 41 (33.1) 75 (30.2) 0.183
Male 86 (69.4) 90 (72.6) 176 (71.0) 0.576
Caucasian 112 (90.3) 116 (93.5) 228 (91.9) 0.351
Non-Hispanic/Latino 90 (72.6) 94 (75.8) 184 (74.2) 0.562
Paroxysmal AF 95 (76.6) 87 (70.2) 182 (73.4) 0.250
Prior cardioversion 47 (37.9) 54 (43.5) 101 (40.7) 0.366
Prior catheter ablation 11 (8.9) 11 (8.9 22 (8.9) 0.563
Mean BMI, kg/m2 (SD) 29.8 (5.7) 28.9 (5.5) 29.4 (5.6) 0.231
CHF 12 (9.7) 9 (7.3) 21 (8.5) 0.494
Hypertension 59 (47.6) 57 (46.0) 116 (46.8) 0.799
Mean systolic BP, mmHg (SD) 133 (16) 131 (18) 132 (17) 0.325
Mean diastolic BP, mmHg (SD) 81 (10) 79 (11) 80 (10) 0.233
Diabetes mellitus 8 (6.5) 14 (11.3) 22 (8.9) 0.180
Prior Stroke/TIA/embolism 0 3 (2.4) 3 (1.2) 0.081
Vascular disease 22 (17.7) 25 (20.2) 47 (19.0) 0.627
Mean CHADS2 Score (SD) 0.7 (0.7) 0.8 (0.9) 0.7 (0.8) 0.179
Mean CHA2DS2-VASc Score (SD) 1.5 (1.3) 1.7 (1.4) 1.6 (1.3) 0.277
Beta blocker, selective 65 (52.4) 61 (49.2) 126 (50.8) 0.611
Antiarrhythmic, class IC 51 (41.1) 49 (39.5) 100 (40.3) 0.796
Antiarrhythmic, class III 30 (24.2) 39 (31.5) 69 (27.8) 0.202
Vitamin K antagonist 36 (29.0) 37 (29.8) 73 (29.4) 0.889
Rivaroxaban 23 (18.5) 29 (23.4) 52 (21.0) 0.349
Dabigatran 12 (9.7) 10 (8.1) 22 (8.9) 0.655
Antiplatelet agent 37 (29.8) 29 (23.4) 66 (26.6) 0.250
Proton pump inhibitor 26 (21.0) 18 (14.5) 44 (17.7) 0.184

Units are listed as n(%) unless otherwise indicated.

BMI, body mass index; BP, blood pressure; CHF, congestive heart failure; ITT, intention-to treat; SD, standard deviation.

Anticoagulation management

The mean estimated compliance rate with rivaroxaban was 99.9 ± 7.1% (SD; n = 123; minimum = 57%). Only one patient had a mean estimated compliance rate of <60%, none were 60–79%, and values for the remaining patients were >80%. The mean rivaroxaban plasma concentration was 151 ± 115 µg/L (n = 103 patients in the rivaroxaban arm of the study). After CA (i.e. during the primary endpoint period), the majority of patients (79.8%) in the VKA treatment group achieved therapeutic anticoagulation as defined by an average INR value of 2.0 to 3.0 (the guideline-recommended and protocol-preferred range). Most patients in the VKA treatment group (87.2%) had an average after-ablation INR value within a range that is likely more reflective of real-world clinical practice (i.e. 1.8 to 3.2). On the day of ablation, the majority of patients had average INR values of 2.0 to 3.0 or 1.8 to 3.2 (52.6 and 64.9%, respectively).

All patients (100%) received heparin on the day of CA (Table 2). The mean total units of heparin administered to achieve the target ACT range was 26% higher for patients in the rivaroxaban treatment group compared with those in the VKA arm (13 871 ± 6516 and 10 964 ± 5912, respectively; P < 0.001). The mean ACT level achieved was 9% lower for patients in the rivaroxaban arm compared with patients in the VKA treatment group (302 ± 49 and 332 ± 58, respectively; P < 0.001).

Table 2.

The practical management of activated clotting time on the day of catheter ablation in the per protocol population

Rivaroxaban VKA Total P Value
N 114 107 221
Patients heparinized, n (%) 114 (100) 107 (100) 221 (100)
N 113 107 221
Total units of heparin, mean (SD) 13 871 (6516) 10 964 (5912) 12 457 (6383) <0.001
N 111 106 218
ACT level, mean (SD) 302 (49) 332 (58) 317 (55) <0.001
N 114 107 221
Protamine for heparin reversal, n (%) 32 (28.1) 27 (25.2) 59 (26.7) 0.634

One total heparin dose value, recorded as 195 000, is not included.

Multiple ACT values were measured for each subject on ablation procedure day. Minimum, median, maximum of ACT values were calculated first for each subject. Summary statistics were then calculated for the minimum, median, and maximum of ACT values. The mean and standard deviation (SD) of the median ACT values is shown. One ACT level exceeded 999 and is not included. Because the system did not accept the ACT value greater than 999, the number 999 was entered in the database for this subject.

ACT, activated clotting time; SD, standard deviation.

Outcomes

There was a similar number (26 vs. 25) of CEC-adjudicated events during the study period among patients in the rivaroxaban and VKA treatment groups (Table 3). For the combined/composite efficacy endpoint, one ischemic stroke and one vascular death were observed in separate patients. Both events occurred in the VKA treatment group at 27 and 14 days after CA, respectively. Throughout the study period, the number of major bleeding events was very low in both treatment groups and consistent across the three definitions of major bleeding events used in this study. There was one ISTH major bleeding event in the VKA treatment group vs. none in the rivaroxaban treatment group. The number of non-major bleeding events (21 vs. 17) was comparable between the rivaroxaban and VKA arms. These events were primarily comprised of procedure-attributable complications, the most frequent of which was haematoma (8 events for rivaroxaban and 10 events for VKA).

Table 3.

The number of CEC-adjudicated outcomes reported during the study period (the number of patients is also shown)

Rivaroxaban VKA Total
Any CEC-adjudicated event 26 25 51
n = 124 n = 124 n = 248
Any thromboembolic events (Composite)a 0 2 2
 Ischemic stroke 0 1 1
 Vascular death 0 1 1
n = 123 n = 121 n = 244
Any bleeding eventsb 21 18 39
 Major bleeding event
 Vascular pseudoaneurysm 0 1 1
 Non-major bleeding events
 Arteriovenous fistula 0 1 1
 Catheter/puncture site haemorrhage 1 1 2
 Contusion 1 1 2
 Ecchymosis 0 1 1
 Epistaxis 2 1 3
 Eye haemorrhage (non-intraocular) 1 0 1
 Gingival bleeding 1 0 1
 Haematoma/vessel puncture site haematoma 8 10 18
 Haematuria 2 0 2
 Haemorrhagic stomatitis 0 1 1
 Mouth haemorrhage 1 0 1
 Urinary tract infection 1 0 1
 Vascular pseudoaneurysm 3 1 4
n = 114 n = 107 n = 221
Any other procedure-attributable eventsc 5 5 10
 Atonic seizures 0 1 1
 Catheter site pain 1 0 1
 Chest discomfort 1 0 1
 Fluid overload 0 1 1
 Local swelling 1 0 1
 Musculoskeletal discomfort 1 0 1
 Pericardial effusion without tamponade 0 1 1
 Postprocedural complication/nausea 1 1 2
 Pyrexia 0 1 1

The eye haemorrhage was not an intraocular bleed (i.e. not a major bleeding event). The two thromboembolic events occurred in separate patients. A 73-year-old male patient died while on a VKA after being hospitalized for a mild episode of cardiac decompensation 11 days after ablation that was resolved 12 days after ablation. The INR was 2.3 on the day of ablation. The patient died suddenly 14 days after ablation. No autopsy was performed. A 71-year-old male on a VKA experienced an ischaemic stroke event 27 days after ablation. The INR was 2.24 on the day of ablation and the prothrombin time was 24.6 on the day after the event. A 62-year-old female on a VKA experienced as vascular pseudoaneurysm CEC-classified as an ISTH major bleeding event 1 day after ablation. The INR was 2.86 on the day of ablation. Fourteen days after the end of the trial, 1 death occurred in a 53-year-old male patient who had been randomly assigned to the rivaroxaban treatment group during the study and then transitioned to VKA and continued on VKA after study-end. On the day before this event, the INR was 5.2. The autopsy indicated that the death was associated with intracranial haemorrhage and hypertension. Major bleeding events were CEC-adjudicated using GUSTO, ISTH, and TIMI criteria (see Appendix for criteria). Events were not counted if they were classified as ‘not a bleeding event’ by the CEC using all three classification methods. The numbers of events for the ITT and safety populations are equal.

aITT population; this total also represents the pre-specified combined/composite efficacy endpoint; non-zero values are listed individually below composite thromboembolic values; there was 1 CEC-adjudicated cardiac event in the VKA arm that the CEC could not further characterize due to absence of sufficient documentation surrounding the event.

bSafety population; the odds ratio (OR) for any bleeding events was 1.178 and 95% confidence interval (95% CI) was 0.593–2.341; for haematoma/vessel puncture site haematoma events, the OR was 0.772 and the 95% CI was 0.294–2.028.

cPer-protocol population; this category includes other non-thromboembolic and non-bleeding procedure-attributable events; for any other procedure-attributable events, the OR was 0.936 and the 95% CI was 0.263–3.328.

Procedure-attributable events not adjudicated as thromboembolic or bleeding events were infrequent and similar (5 vs. 5) among patients in the rivaroxaban treatment group compared with those in the VKA arm. Other procedure-attributable complications included, for example, one reported episode of chest pain in the rivaroxaban arm and one occurrence of pericardial effusion without tamponade in the VKA arm.

Serious adverse events

The number of SAEs leading to drug discontinuation were very low and similar in the rivaroxaban and VKA treatment groups [1(0.8%) vs. 3(2.5%), respectively]. The number of SAEs leading to hospitalization were similarly low in the rivaroxaban treatment group [11(8.9%)] and in the VKA treatment group [17(14.0%)].

Discussion

VENTURE-AF is the first randomized prospective comparative trial of an uninterrupted NOAC vs. VKA therapy in patients with AF undergoing CA. Due to expected low event rates, VENTURE-AF was intentionally designed as an exploratory study and thus no formal statistical superiority or non-inferiority analysis was planned. Major outcome rates were low, validating our design assumptions. The incidence of primary safety events was low in the general population (0.4%; one event in a VKA patient), with no such event being reported in rivaroxaban patients. Similarly low was the overall incidence of composite thromboembolic events (0.8%; two events, in separate VKA patients). The overall complication rate was 20.6%. Bleeding and thromboembolic events represent the most common complication in patients undergoing CA of AF.1921

The use of vitamin K antagonist peri-CA has become the practice standard.2,2224 The use of NOACs is increasing among AF patients undergoing CA.25 Results of non-randomized studies using various dose-timing protocols suggest that the use of an NOAC may be feasible in such patients.3,11,21,2528 In contrast, one retrospective study of uninterrupted VKA or dabigatran vs. a bridged VKA strategy reported a higher complication rate in the uninterrupted cohort.29

The observation that a slightly higher total dose of heparin may be needed to achieve target ACT range among patients in the rivaroxaban arm compared with those in the VKA treatment group is consistent with all NOACs as reported in a retrospective cohort study from a prospective AF ablation registry maintained at a large, academic medical centre.30 Although the mechanistic basis for this observation may not be known, evidence in this study confirms the clinician's ability to successfully and practically manage ACT levels in this setting.

There are several limitations in this study. The VENTURE-AF exploratory sample size reflects the infeasibility of conducting a large, fully-powered study based on standard calculations. Although the low incidence of events likely represents a population of highly skilled electrophysiologists performing CA of AF, this element could reduce the sensitivity of the read-out. The open-label design can also introduce bias related to knowledge of treatment allocation.

Despite these limitations, several findings substantiate the strength of the results of VENTURE-AF. First, this study used a randomized multicentre international trial design. Secondly, blinded-adjudication of events reduced potential reporting bias. Thirdly, the sample size is similar in magnitude to the largest reported studies in this setting. Additionally, the provision of detailed outcomes data added meaningful robustness. Finally, the number of bleeding events was generally consistent across three different sets of criteria, further supporting the consistency of study findings.

Conclusions

The use of uninterrupted rivaroxaban in patients undergoing CA for NVAF is feasible and the number of events was low and similar to that for uninterrupted dose-adjusted VKA.

Funding

This study was sponsored and funded by Janssen Scientific Affairs LLC, a Johnson and Johnson Company and by Bayer HealthCare Pharmaceuticals. Funding to pay the Open Access publication charges for this article was provided by Janssen Scientific Affairs LLC, a Johnson and Johnson Company.

Conflict of interest: All authors received research grant support from the sponsors of the trial (Johnson & Johnson and Bayer). G.V.N. is a consultant for Glaxo-Smith-Kline, Pfizer, Xention, Sanofi, Bristol Myers Squibb, Merck, Biosense-Webster, Janssen, Otsuka, Daiichi-Sankyo, and Boehringer-Ingelheim. R.C. Biosense Webster, St Jude Medical, and Bard. S.H.H. consulting and lecture fees from Boehringer Ingelheim, BMS, Bayer, Pfizer, and Sanofi-aventis. F.E.M. consulting and lecture fees from Biosense Webster, Medtronic, St Jude Medical and Cardioinsight. D.J.W. received lectures and consulting fees from Biosense Webster, Medtronic, St Jude, Cardioinsight and research support from Biosense Webster, Medtronic. C.M. received no further disclosures. D.W.D. is a consultant for Boston Scientific, Janssen, Medtronic, and Rhythmia. A.N. Biosense Webster, Boston Scientific, Janssen, St Jude Medical, Medtronic, and Biotronik. D.S.W. Speaking/Honorarium/Consulting-Medtronic; Speaking/Honorarium-Bristol Myers Squibb. B.J.H. received lecture fees from Bayer Healthcare Pharmaceuticals. J.V. has no personal conflicts of interest; the division of Electrophysiology received research grants from Medtronic and St Jude Medical. C.D.C. gave a lecturer for St Jude Medical, Medtronic, Biotronik, and MEDA PHARMA. L.E.F. is an employee of Johnson & Johnson at Janssen Scientific Affairs, LLC. J.Xiang, PhD: is an employee of Johnson & Johnson at Janssen Research & Development, LLC. Susanne Hess, MD: is an employee of Bayer at Bayer HealthCare Pharmaceuticals.

Acknowledgements

The VENTURE-AF Steering Committee thanks participants and their caregivers and families, VENTURE-AF investigators and their teams; the VENTURE-AF Core Integrated Team and colleagues.

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