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. 1994 Oct 25;91(22):10695–10699. doi: 10.1073/pnas.91.22.10695

Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis.

F W Jacobsen 1, M Rothe 1, L Rusten 1, D V Goeddel 1, E B Smeland 1, O P Veiby 1, L Slørdal 1, S E Jacobsen 1
PMCID: PMC45088  PMID: 7524102

Abstract

Biological effects of tumor necrosis factor alpha (TNF-alpha) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal hematopoiesis. Using agonists (antibodies) specific for the 55- and 75-kDa TNF receptors, we demonstrate differential roles of the two TNF receptors in hematopoiesis in that only the 55-kDa TNF receptor mediates antiproliferative effects of TNF-alpha on mature Lin- hematopoietic progenitor cells responding to granulocyte colony-stimulating factor or interleukin 3 alone. In contrast, the 75-kDa TNF receptor is essential in mediating inhibition of primitive Lin-Sca-1+ high-proliferative-potential colony-forming cells and inhibition of the total number of proliferative clones of individually cultured Lin-Sca-1+Rh123lo and Lin-Sca-1+Rh123hi cells.

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Selected References

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