Figure 4.

(A) Tumor growth studies in a mouse A431 xenograft model after intravenous administration of DAB-LF dendriplex carrying plasmid DNA encoding TNFα (50 μg/injection) (green), DAB-LFC dendriplex (blue), DAB dendriplex (orange), DAB-LF dendriplex carrying a non-therapeutic DNA encoding β-galactosidase (pale green), DAB-LFC dendriplex carrying a non-therapeutic DNA encoding β-galactosidase (pale blue), naked DNA (red) and untreated tumors (back) (n = 10).

(B) Variations of the animal body weight throughout the treatment (Color coding as in (A)).

(C) Overall tumor response to treatments at the end of the study.

(D) Time to disease progression. The Y axis gives the proportion of surviving animals over time. Animals were removed from the study once their tumor reached 11 mm diameter (Color coding as in (A)).