The authors wish to retract the article titled “Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis,” which was published in the June 15, 2010, issue of Cancer Research (1). This study investigated the mechanisms by which miR-31 regulates different aspects of breast cancer metastasis. The authors have retracted their earlier publication (2) because original data were compiled from different replicate experiments in order to assemble certain figure panels, leading to comparisons of selectively chosen data points from multiple experiments. As the same analytical methodology was used in this article, the authors believe that the responsible course of action is to retract it. The authors apologize for any inconvenience they have caused.
Footnotes
All of the authors have agreed to this Retraction.
Contributor Information
Scott Valastyan, Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Amelia Chang, Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Nathan Benaich, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, and Department of Biology, Williams College, Williamstown, Massachusetts.
Ferenc Reinhardt, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
Robert A. Weinberg, Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts, Institute of Technology, and MIT Ludwig Center for Molecular Oncology, Cambridge, Massachusetts
References
- 1.Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA. Concurrent suppression of integrin α5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res. 2010;70:5147–54. doi: 10.1158/0008-5472.CAN-10-0410. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
- 2.Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell. 2009;137:1032–46. doi: 10.1016/j.cell.2009.03.047. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]