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. 1994 Nov 8;91(23):10918–10922. doi: 10.1073/pnas.91.23.10918

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

X Q Qin 1, D M Livingston 1, W G Kaelin Jr 1, P D Adams 1
PMCID: PMC45137  PMID: 7971984

Abstract

E2F-1 is a transcription factor suspected of activating genes required for S phase and a known target for the action of RB, the retinoblastoma gene product. Its induction in quiescent fibroblasts led to S-phase entry followed by apoptosis. E2F-1-mediated apoptosis was suppressed by coexpression of wild-type RB or a transdominant negative mutant species of p53. In contrast, coexpression of a naturally occurring loss-of-function RB mutant or wild-type p53 did not suppress the induction of apoptosis under these conditions. Thus, deregulated E2F-1 activity gives rise to proliferative and apoptotic signals. p53 appears to participate in the execution of the latter.

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Selected References

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