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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Oncogene. 2015 Jan 26;34(41):5288–5294. doi: 10.1038/onc.2014.455

Figure 4. CT8 interferes with the movement of HER3 into the Sec61 channel.

Figure 4

Schematic model showing the mode of action of CT8. CT8 blocks the movement of the HER3 signal peptide helix into the Sec61 membrane channel as the nascent protein emerges from the ribosome, ultimately leading to its proteasome-dependent degradation.