Table 1.

Baseline characteristics

	Pooled placebo	0.5 mg LAQ	1.0 mg LAQ	1.5 mg LAQ	2.0 mg LAQ (n=29)
N	63	29	30	29	29
Age, years mean (SD)	35.1 (10.9)	39.6 (14.8)	38.2 (11.3)	40.9 (14.5)	37.4 (9.9)
Female %*	42.9	55.2	56.7	72.4	58.6
Predominately inflammatory disease %†	54.0	75.9	66.7	41.4	41.4
CDAI score mean (SD)	311.2 (74.5)	288.3 (56.0)	291.9 (57.5)	297.8 (59.1)	313.2 (58.9)
CRP concentration (mg/L)	21.3 (27.8)	17.1 (18.3)	6.7 (12)	15.1 (22.3)	6.5 (17.1)
Median (IQR) Min–max	1.8–85.7	2.2–127.5	1.0–153.6	1.0–79.8	1.0–153.2
CRP ≥5 mg/L at baseline %	81	86	57	66	45
Faecal calprotectin concentration (µg/g) median (IQR)	475 (802)	468 (1434)	543 (813)	318 (500)	270 (422)
Min–max	19.0–6559	15.0–6551	15.0–5563	18.0–8000	15.0–3994
Faecal calprotectin concentrations ≥250 µg/g at baseline %	69.8	62.1	60	51.7	37.9
Previous CD operations %	33.3	17.2	40.0	44.8	44.8
Current treatment with either azathioprine, 6-mercaptopurine or methotrexate %	31.7	27.6	36.7	37.9	24.1
Current treatment with 5-aminosalicylates %	36.5	27.6	43.3	34.5	41.4
Current treatment with antibiotics %	4.8	6.9	3.3	0	3.4
Current treatment with steroids %	27	34.5	40	31	17.2
Previous use of anti-TNF in past year %	42.9	27.6	16.7	41.4	41.4

*% indicates per cent of patients.

†Montreal definition.

CD, Crohn's disease; CDAI, CD Activity Index; TNF, tumour necrosis factor.