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. 2015 Jun 29;7(7):5217–5238. doi: 10.3390/nu7075217

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Tissue NO production in control and arginase-treated animals with l-arginine or l-citrulline supplementation. (A) The expected arginase-induced decrease in jejunal NO production, determined as pmol mono-nitrosyl iron complex (MNIC)/mg wet tissue, was not present in the arginase + l-citrulline-treated group, whereas in the l-arginine-treated group, the NO production was not enhanced. (B) l-citrulline and l-arginine supplementation both resulted in an enhanced NO production in the liver of arginase-treated animals. (C) Arginase infusion did not decrease the renal NO production compared to control treated animals. l-arginine supplementation significantly increased renal NO concentration in arginase-treated animals, while l-citrulline only tended to increase the NO levels. Significance: ^a p < 0.05 vs. control; ^b p < 0.05 vs. arginine; ^c p < 0.05 vs. arginine + arginase; ^d p < 0.05 vs. citrulline + arginase.

Tissue NO production in control and arginase-treated animals with l-arginine or l-citrulline supplementation. (A) The expected arginase-induced decrease in jejunal NO production, determined as pmol mono-nitrosyl iron complex (MNIC)/mg wet tissue, was not present in the arginase + l-citrulline-treated group, whereas in the l-arginine-treated group, the NO production was not enhanced. (B) l-citrulline and l-arginine supplementation both resulted in an enhanced NO production in the liver of arginase-treated animals. (C) Arginase infusion did not decrease the renal NO production compared to control treated animals. l-arginine supplementation significantly increased renal NO concentration in arginase-treated animals, while l-citrulline only tended to increase the NO levels. Significance: ^a p < 0.05 vs. control; ^b p < 0.05 vs. arginine; ^c p < 0.05 vs. arginine + arginase; ^d p < 0.05 vs. citrulline + arginase.