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. 1994 Nov 8;91(23):11158–11162. doi: 10.1073/pnas.91.23.11158

Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.

U Stäubli 1, Y Perez 1, F B Xu 1, G Rogers 1, M Ingvar 1, S Stone-Elander 1, G Lynch 1
PMCID: PMC45186  PMID: 7972026

Abstract

An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an analogue of 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine that was also found to improve retention of memory in a radial maze task and in an odor-matching problem. These results define tools for enhancing long-term potentiation in vivo and confirm an important prediction from the hypothesis that long-term potentiation is a substrate of memory.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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