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. 1994 Nov 8;91(23):11187–11191. doi: 10.1073/pnas.91.23.11187

Enteric immunization of mice against influenza with recombinant vaccinia.

C A Meitin 1, B S Bender 1, P A Small Jr 1
PMCID: PMC45192  PMID: 7972032

Abstract

Intrajejunal administration to mice of a recombinant vaccinia virus containing the influenza virus hemagglutinin gene induced IgA antibody in nasal, gut, and vaginal secretions. It also induced IgG antibody in serum and cell-mediated immunity. The immunization provided significant protection against an influenza virus challenge. This work suggests that enteric-coated recombinant vaccinia could be an orally administered, inexpensive, multivalent, temperature-stable, safe, and effective vaccine for children that could be particularly useful in developing nations, where multiple injections are not easily administered. Oral administration of vaccines should also reduce children's fear of shots at the doctor's office.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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