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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Neuropsychology. 2015 Feb 2;29(5):675–682. doi: 10.1037/neu0000175

Self Assessment in Schizophrenia: Accuracy of Evaluation of Cognition and Everyday Functioning

Felicia Gould 1, Laura Stone McGuire 1, Dante Durand 1, Samir Sabbag 1, Carlos Larrauri 1, Thomas L Patterson 2, Elizabeth W Twamley 2,3, Philip D Harvey 1,4
PMCID: PMC4522405  NIHMSID: NIHMS655995  PMID: 25643212

Abstract

Objective

Self-assessment deficits, often referred to as impaired insight or unawareness of illness, are well established in people with schizophrenia. There are multiple levels of awareness, including awareness of symptoms, functional deficits, cognitive impairments, and the ability to monitor cognitive and functional performance in an ongoing manner. The present study aimed to evaluate the comparative predictive value of each aspect of awareness on the levels of everyday functioning in people with schizophrenia.

Method

We examined multiple aspects of self-assessment of functioning in 214 people with schizophrenia. We also collected information on everyday functioning rated by high contact clinicians and examined the importance of self-assessment for the prediction of real world functional outcomes. The relative impact of performance based measures of cognition, functional capacity, and metacognitive performance on everyday functioning was also examined.

Results

Misestimation of ability emerged as the strongest predictor of real world functioning and exceeded the influences of cognitive performance, functional capacity performance, and performance-based assessment of metacognitive monitoring. The relative contribution of the factors other than self-assessment varied according to which domain of everyday functioning was being examined, but in all cases, accounted for less predictive variance.

Conclusions

These results underscore the functional impact of misestimating one’s current functioning and relative level of ability. These findings are consistent with the use of insight-focused treatments and compensatory strategies designed to increase self-awareness in multiple functional domains.

Keywords: schizophrenia, insight, cognition, metacognition, functional capacity


Poor insight is a well-documented feature of schizophrenia, including reduced awareness of having a mental disorder, need for treatment, and the consequences of the illness (Amador et al., 1994; Medalia & Thysen, 2010). Awareness of functional deficits a on the part of people with schizophrenia has consistently been found to be inaccurate compared to observations of high-contact clinicians and interviewers (Bowie et al., 2007; Durand et al., 2014; Johnson et al., 2011; Sabbag et al., 2011). There are multiple strategies for assessing real-world functioning, including rating scales completed by informants and patients (Leifker et al., 2011; Gould et al., 2012), direct observations by trained clinicians (Kleinman et al., 2009), and performance-based measures of the ability to perform everyday skills (Harvey et al., 2007). Multiple areas of everyday functioning are affected in people with schizophrenia, including deficits in social, vocational, and everyday activities domains, even during periods of remission from active psychosis (Leung et al., 2008). Self-reports of everyday functioning in schizophrenia often do not converge with objective evidence, including performance-based assessments of cognition or functional capacity (Bowie et al., 2007; Sabbag et al., 2011, Durand et al., 2014) or the reports of other evaluators (Patterson et al., 1997; McKibbin et al., 2004).

Three domains of impaired awareness have been documented including: clinical insight (often referred to as Unawareness of illness: Amador et al., 1993), cognitive insight, including cognitive distortions such as overgeneralizations (Beck et al., 2004), and neurocognitive insight or awareness of neuropsychological dysfunction (Medalia & Thysen, 2008; Burton et al, 2014 submitted). Some data suggest that having insight in one domain does not necessarily equate to insight in another domain (Medalia & Thysen, 2010). In a separate analysis of the present dataset, Burton et al. (2014, submitted) compared participants with and without neurocognitive impairment on self-report measures of awareness of cognitive difficulties, depression, positive and negative symptoms, and performance-based measures of executive functioning and functional capacity. The groups differed only with respect to positive symptoms and depression, in that depression and positive symptoms appeared to be associated with enhanced neurocognitive insight. Durand et al., (2014) also conducted an investigation of neurocognitive insight in this sample, but focused on self-reports of cognitive deficits as they related to reports of high contact clinicians. Similar to Burton et al. (2014, submitted), they also found that depression was associated with greater convergence between self-reported cognitive performance and clinician impressions.

One previous investigation found a relationship between the executive functioning measured by the Wisconsin Card Sorting Test (WCST) and cognitive insight, but no relationship between misestimation of cognitive functioning and other domains of neurocognition such as attention, memory and problem solving (e.g., Simon et al., 2009). Individuals with poorer neuropsychological (NP) functioning have been shown to underestimate their impairment and functional capacity across multiple neuropsychiatric conditions (e.g., Carone et al., 2005, Spikman and van der Naalt, 2010). Koren at al. (2006) used an adaptation of the WCST to investigate metacognitive processing, including self-monitoring and self-regulation, finding that they were essential determinants of real world functioning and self-assessment (Koren et al., 2006). Further, Koren et al. (2004) found that metacognition was a mediator between cognitive deficits and misestimation of functioning, with measures of metacognition relating more strongly to the ability to self-assess as compared with traditional NP assessment measures.

The present study performed a wide-ranging examination of impaired self-assessment in schizophrenia, including everyday functioning, cognitive abilities, and contemporaneous assessment of accuracy of performance in a cognitive test. Previous studies have found that the range of abilities and symptoms in people with schizophrenia account for 50% or less of the variance in real-world functioning (Bowie et al., 2006; 2008); it is possible that mis-estimation of abilities and functioning could account for additional variance. We examined the association of impaired self-assessment and everyday functioning, beyond the influences of other determinants, such as NP performance and level of everyday functioning. We also examined whether contemporaneous self-assessment deficits underlie other self-assessment deficits. Such an investigation is even more important in light of previous research suggesting that metacognitive deficits can be targeted via psychotherapeutic interventions (i.e., Brune, Dimaggio, & Lysaker, 2011). We examined the discrepancies between self-report and informant judgments across three domains of everyday functioning: vocational function, interpersonal skills, and everyday activities, as well as the discrepancy between self-assessed and informant-rated cognitive performance. If metacognitive impairment (impairment in the ability to perform contemporaneous judgments of adequacy in the performance of cognitive tests) is a primary predictor of self-assessment of everyday functional skills, it would be expected that impairments in this domain would add to the influences of previously identified determinants of impaired self-assessment.

Method

Participants

This research is part of the VALERO 2 study, which aimed to identify best methods for rating everyday functioning in individuals with schizophrenia and to identify potential determinants of impaired self-assessment (Harvey et al., 2011). The study participants included outpatients with schizophrenia (n=214) residing in Atlanta, Miami, or San Diego. Two informants were interviewed for each study participant: a high-contact clinician (case manager, psychiatrist, therapist, or residential facility manager) and a friend or relative. All research participants and informants provided signed, informed consent, and the study was approved by appropriate local IRBs in Miami, Atlanta, and San Diego. Participants in Atlanta were recruited at a psychiatric rehabilitation program (Skyland Trail). In Miami, they were recruited from the outpatient population at the University of Miami Medical Center. In San Diego, participants were recruited from the UCSD Outpatient Psychiatric Services clinic, a large public mental health clinic, and other local community clinics and by word of mouth. Table 1 presents the demographic and clinical characteristics of the sample.

Table 1.

Demographic and Clinical, and Performance Variables in the VALERO II Patient Sample with Schizophrenia

N=214
Characteristic n %
Male 139 65
Race
  Caucasian 117 55
  African American 77 36
  Other 20 9.3
  Hispanic Ethnicity 50 23.4
Mean SD
Age (Years) 41.0 12.4
Education 12.3 2.2
Mood and Performance Variables Mean SD
Beck Depression Inventory 15.33 11.68
UPSA-B Total Score 70.57 14.98
MCCB / Global NP T Score 37.41 8.71

Metacognition Mean SD
Koren Accuracy Score 36.48 13.44
Koren Global Monitoring 25.30 14.47

Note. Accuracy scores can range from 0-64

All participants were administered a structured diagnostic interview, the Mini International Neuropsychiatric Interview, 6th Edition (MINI; Sheehan et al., 1998) by a trained interviewer. All diagnoses were subjected to a consensus procedure at each site. Participants were excluded for a history of traumatic brain injury with unconsciousness >10 minutes, brain disease including seizure disorder or neurodegenerative condition, or the presence of another DSM-IV diagnosis that would exclude the diagnosis of schizophrenia. None of the participants were experiencing their first psychiatric episode. Comorbid substance use disorders were not an exclusion criterion, in order to capture a broad array of individuals with schizophrenia, but participants who appeared intoxicated were rescheduled. Inpatients were not recruited. Participants resided in a wide array of unsupported, supported, or supervised residential facilities. Informants were not screened for psychopathology or substance abuse.

Procedure

All participants were examined with a performance-based assessment of metacognition, neurocognitive abilities, and functional capacity. Participants and informants also provided reports of social, everyday activities, and vocational functioning by completing a series of questionnaires and interview-based procedures. Although there were two informants for each participant, a friend or relative or a high contact clinician, we used the high contact clinician ratings for this study because of previous evidence that they had greater validity in the VALERO I study (Sabbag et al., 2011). Informants received no training and had no information about any performance based, clinically rated, or self-reported data on the participants.

Measures

Clinical Symptom Ratings

The severity of positive and negative symptoms was rated with Positive and Negative Symptom Scale (PANSS; Kay, 1991), a 30-item scale. Participants self-reported the severity of depression with the Beck Depression Inventory-II (BDI-II; Beck et al., 1996), with scores presented in Table 2.

Table 2.

Cognition, Functional Capacity, Meta-Cognition, Symptoms, and Everyday Functional Outcomes

Clinician Ratings Difference Scores
(Patient – Interviewer)
Variable Mean SD Mean SD
SLOF Interpersonal Subscale 22.45 5.97 2.25 8.36
SLOF Activities Subscale 44.40 10.66 4.04 13.05
SLOF Vocational Subscale 20.06 5.29 3.52 7.00
Cognitive Assessment Inventory 27.96 10.33 −4.40 12.48

Note.

Higher scores on the SLOF difference scores reflect patients reporting less impairment.

Lower scores on the Cognitive assessment inventory difference scores reflect patients reporting less impairment

Neurocognition

We examined cognitive performance with a modified version of the MATRICS consensus cognitive battery (MCCB; Nuechterlein et al., 2008). For this study, we did not include the social cognition measure from the MCCB, the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) because several recent meta-analyses (e.g., Fett et al., 2011; Ventura et al., 2013) found that social cognition measures are minimally correlated with neurocognitive test performance and that neurocognition and social cognition are associated with different outcomes. We calculated a composite score, an average of the 9 age-corrected T-scores based on the neurocognitive tests in the MCCB, using the MCCB normative program, as our critical dependent variable.

Functional Capacity

As a functional capacity measure, we administered the brief version of the UCSD Performance-based Skills Assessment (UPSA-B; Mausbach et al., 2007). The UPSA-B is a measure of functional capacity, wherein participants are asked to perform everyday tasks related to communication and finances. The Communication subtest involves role-play exercises using an unplugged telephone (e.g., making an emergency call; dialing a number from memory; calling to reschedule a doctor’s appointment). During the Finance subtest, participants read a utility bill, count change, and write a check to pay a bill. The UPSA-B requires approximately 10 minutes. A total score is calculated from raw scores and ranges from 0-100, with higher scores indicating better functional capacity.

Real-World Functional Outcomes

As previously reported in the initial phase of the VALERO study, everyday functioning rated with multiple rating scales was correlated with neuropsychological and functional capacity performance (Harvey, Raykov, et al., 2011). The best rating scale determined by its relationship with ability measures was the Specific Levels of Functioning (SLOF; Schneider and Struening, 1983) scale, a self- or informant-rated report of functioning in Interpersonal Relationships (e.g., initiating, accepting and maintaining social contacts, effectively communicating), Participation in Community and Household Activities (shopping, using the telephone, paying bills, use of leisure time, use of public transportation), and Work Skills (e.g., employable skills, level of supervision required to complete tasks, ability to stay on task, completes tasks, punctuality). The SLOF’s Physical Functioning, Self-Care, and Socially Acceptable Behavior subscales were not used in the VALERO study. Patients were interviewed by a rater and informants completed the scale as questionnaire.

Metacognition

Using a metacognitive adaptation of the Wisconsin Card Sorting Test (Koren et al., 2004; 2006), we examined subjects’ abilities to evaluate the accuracy of their neuropsychological performance and to quantify their metacognitive abilities. We administered the Wisconsin Card-Sorting Test (64-card version) and asked subjects to rate on a 100-point scale their confidence in the correctness of each response and to decide whether they wanted the response to count toward their total score. Thus, performance can be split into domains of accuracy (correct sorts), appraisal (average confidence for correct and incorrect sorts), and judgment (proportion of responses “offered” as correct as a function of actual accuracy).

In this study, accuracy and global monitoring were the dependent variables due to their previously manifesting the strongest and most consistent correlations with everyday functioning. Accuracy is the number of correct responses. Global monitoring is the total number of correct sorts the participant asks to be counted minus the incorrect sorts that they ask to be counted, indexing the participants’ sense of their own knowledge level. The combination of these metacognitive indicators provides moment-to-moment performance data on metacognitive insight.

Self-reported and Interviewer Rated Cognitive Functioning

Both patients and high contact clinicians completed the Cognitive Assessment Inventory (CAI; Ventura, et al., 2013). The CAI is a 10-item instrument, which asks the participant to rate the severity of impairments in a variety of cognitive domains. Ratings are generated with on a 6-point (1-6) scale: a score of 1 indicates the least impairment, and a score of 6 represents most impairment. The patient was asked the questions in a standard interview format. Clinicians completed the form by themselves using the same instructions that the interviewer provided to the patients to rate the patient’s level of cognitive impairment. For this analysis, we calculated a total score for the clinician and self-reports on the CAI. We previously reported that scores on the CAI were uncorrelated between patient and clinician appraisals and that clinician ratings were significantly correlated with MCCB performance, while self-reported performance on the CAI was uncorrelated with the MCCB (Durand et al., 2014).

Results

Table 1 presents descriptive information on the patient sample. Also presented in Table 1 are all of the predictor variables, including the UPSA-B, modified MCCB, BDI-II, PANSS negative symptoms, metacognitive measures from the adapted WCST, and CAI scores. Table 2 presents informant ratings and difference scores for the three subscales on the SLOF (interpersonal functioning, everyday activities, and vocational functioning), with informant-based SLOF scores and CAI scores subtracted from the patient self-reported SLOF and scores. This subtraction procedure leads to higher scores on SLOF difference scores reflecting participant impressions of less impairment than seen by their clinicians, while lower scores on the CAI difference scores reflect participant impressions of less impairment on cognition measured by the CAI compared to their clinician raters.

Distributions

We examined the distributions of discrepancy scores because we wanted to examine normality of the distributions and to ensure that inaccurate self-assessment included both over and under-estimation of performance compared to the clinician reference points. None of the four difference scores had significant kurtosis or skewness. Although there was a general tendency toward participant underestimation of impairment across all three functional domains and for cognition, a substantial proportion of participants accurately estimated their functioning and an additional proportion of participants underestimated their performance compared the clinician ratings. For example, for work skills, 33% of the participants rated their performance equivalent to or poorer than their clinicians; this proportion was 47% for everyday activities and 44% for social functioning. Thus, slightly more than half of the participants overestimated their everyday functioning. For the CAI, 40% of participants reported their functioning to be equivalent to or worse than interviewer ratings. Thus, although over-estimation was more common, the difference scores were not unidirectional.

Correlations with Real World Functioning

Next, we computed Pearson correlations between the predictor variables, including clinician CAI ratings, and the clinician informant SLOF scores. As can be seen in Table 3, there were consistent correlations between clinician ratings of vocational functioning, everyday activities, and interpersonal relationships and all of the performance-based predictor variables, with only two correlations failing to reach statistical significance (both involving interpersonal functioning).

Table 3.

Correlations Between Clinician-rated Functioning vs. Cognition and Symptoms

SLOF Interviewer Ratings UPSA-B Total CAI Global NP
T Score
Koren Global
Monitoring
Koren
Accuracy
R2
SLOF Interpersonal Subscale 0.26** −.06 0.16* −0.11 0.17* 0.17
SLOF Activities Subscale 0.28** −.28** −0.21** −0.21** 0.22** 0.26
SLOF Vocational Subscale 0.31** −.42** −0.26** −0.26** 0.25** 0.22

SLOF Difference Scores Between Clinician Ratings and Self-reports
UPSA-B Total CAI Δ Global NP
T Score
Koren Global
Monitoring
Koren
Accuracy
R2
SLOF Interpersonal Subscale −0.15* −0.43** −0.20** −0.22** −0.23** 0.25
SLOF Activities Subscale −0.07 −0.49** −0.24** −0.11 −0.16 0.25
SLOF Vocational Subscale −0.09 −0.39** −0.08 0.17* −0.10 0.18
**

p <0.01

*

p<0.05

Note: All variance accounted for in simultaneous regressions with all variables entered in to the equation.

Correlations with Self-Assessment of Everyday Functioning

In the next analyses, we examined the intercorrelation between indicators of accuracy of estimation of current functioning. For these analyses, we used the CAI discrepancy scores as predictors. These correlations are presented in the bottom of table 3. Greater mis-estimation of vocational functioning was significantly correlated with the greater mis-estimation of cognitive functioning, poorer metacognition/global monitoring, and lower depression scores. Greater misestimation of activities was significantly correlated with the greater mis-estimation of cognitive functioning, poorer global NP performance and lower depression scores. Greater misestimation of social functioning was significantly correlated with the greater misestimation of cognitive functioning, poorer global monitoring and reduced accuracy, and poorer functional capacity.

Regression Models

We then calculated simultaneous entry linear regressions as a test to confirm an overall relationship between real-world functioning and the following predictors: neuropsychological functioning (NP) as indexed by overall performance on the MCCB, performance on the UPSA-B, neurocognitive insight as determined by patient and interviewer discrepancies on the CAI, and metacognitive performance as indexed by accuracy and global monitoring on the adapted WCST. The models were significant for all 3 analyses, all F>8.47, all p<.001.

Based on the results of the simultaneous regressions, stepwise entry regressions were calculated to ascertain the importance of the different predictors of everyday functioning. These results are presented in the top of Table 4. When vocational functioning was examined, UPSA performance predicted 11% of the variance within the model, with the self-assessment discrepancy scores on the CAI predicting an additional 7% of the variance. Metacognitive performance on the WCST contributed an additional 4% of the variance. When social functioning was examined, self-assessment discrepancy scores on the CAI predicted 12% of the variance within the model and UPSA performance predicted 4% of the variance within the model, but metacognitive performance on the WCST did not enter the model. Similarly, when everyday activities were examined, the CAI discrepancy score predicted 17% of the variance within the model, and global NP performance predicted an additional 9% of the variance, but metacognitive performance did not enter into the model.

Table 4.

Regression Analyses

Stepwise Regression Analyses Predicting Real World Outcomes
SLOF Interviewer Ratings Step Variable(s) P R2
SLOF Interpersonal Functions 1 CAI Δ <.001 .12
2 UPSA-B Total <.001 .17
SLOF Activities Subscale 1 CAI Δ <.001 .17
2 Global NP T score <.001 .26
SLOF Vocational Subscale 1 UPSA-B Total <.001 .11
2 CAI Δ <.001 .18
3 Koren Global Monitoring <.001 .22

Derived Global Misestimation of Functioning Score Predicting Real world outcomes
SLOF Interviewer Ratings Step Variable(s) P R2
SLOF Interpersonal Functions 1 Misestimation score <.001 .29
2 UPSA-B Total <.001 .31
SLOF Activities Subscale 1 Misestimation score <.001 .42
2 Global NP T score <.001 .45
SLOF Vocational Subscale 1 Misestimation score <.001 .37
2 UPSA-B Total <.001 .42

To test the idea that deficits in the contemporaneous monitoring of performance were the driver of more global self-assessment errors, we used a forced entry regression strategy. We entered the WCST accuracy and monitoring variables in the first step in a regression model, with UPSA scores and CAI self-assessment discrepancy scores entered in the second block, to predict each of the SLOF self-assessment discrepancy scores. When vocational functioning was examined via forced entry regression modeling, the two metacognitive performance variables on the WCST did not significantly enter the equation. However, the other factors (UPSA, Global NP and self-assessment discrepancy scores on the CAI) accounted for 18 % of the variance (R2=.18, F=11.18, p<.001). However, when social functioning was examined, metacognitive performance measures predicted 6% of the variance within the model (R2=.06, F= 9.05, p<0.005) and the other predictors (UPSA, Global NP and self-assessment discrepancy scores on the CAI) predicted another 19% of the variance within the model (R2=.25, F=12.44, p<.001). With respect to everyday activities, the metacognitive measures predicted 3% of the variance within the model (R2=.03, F=1.94, p<.001), and the other predictors (UPSA, Global NP and self-assessment discrepancy scores on the CAI) accounted for an additional 22% of the variance (R2=.25, F=15.82, p<.001).

The intercorrelations observed between different measures of self-assessment of functioning as indexed by interviewer/clinician and patient rating discrepancies on the CAI and SLOF indices were relatively high. Thus, an unrotated principal components analysis was conducted to create a global index of discrepancies in self-assessment of functioning using patient and interviewer discrepancies on the CAI and each of the three SLOF domains (social, vocational, and everyday activities). The resulting principal component was then placed into a stepwise regression model (Bottom of Table 4) to determine how it functioned as a predictor of every day functioning compared to NP and functional capacity measures. When we examined the prediction of clinician rated everyday activities, the self-assessment discrepancy factor score predicted 42% (R2=.42, F=107.62, p<.001) of the variance and NP performance contributed an additional 3% of the variance (R2=.45, F=60.22, p<.001). When vocational outcomes were analyzed, the self-assessment discrepancy factor score contributed 37% (R2=.37, F=87.75, p<.001) of the variance; UPSA scores contributed an additional 5% of the variance (R2=.42, F=53.29, p<.001). Finally, when social functioning and interpersonal outcomes were examined, the self-assessment discrepancy factor score contributed to 29% (r2=.29, F=60.51, p<.001) of the variance; UPSA performance contributed an additional 2% of the variance (r2=.31, F=53.29, p<.001).

In order to ensure that prediction everyday outcomes with difference scores was not yielding a biased result because the clinician rating of each domain is a component of the difference score, we recalculated the analyses for each of the three SLOF variables. For each analysis we excluded the domain specific difference score (e.g., excluding the difference score for everyday activities from the principal component score predicting clinician ratings of everyday activities) and recalculated the principal component, using it to predict the everyday outcomes. These analyses did reduce the variance accounted for: in SLOF everyday activities the new variance accounted by the global estimation variable was reduced to 28%, while for vocational activities the new variance accounted for was 25% and for social outcomes it was 15%. Thus, eliminating the domain-specific difference score did not eliminate the influence of self-assessment discrepancies on everyday outcomes and impaired self-assessment of functioning was still the most substantial predictor of real world functional outcomes.

Discussion

In this study discrepant self assessment of functioning across different domains including cognitive functioning and real world outcomes emerged as the single greatest predictor of real world functioning (social, vocational and everyday activities). This was true even when we controlled for any inherent overlap or intercorrelations in our predictor and outcome variables. Importantly, among those participants who misestimated their functioning, there was a general trend toward overestimation of functioning. The variance in real world outcomes accounted for by inaccurate estimation of functioning was actually greater than the variance accounted for by ability variables, including both NP performance and functional capacity. Although this is a cross-sectional study, it appears as though patient with the greatest impairments in judging their functioning also have the greatest level of impairments in real world outcomes.

Some support for our hypothesis that momentary monitoring would contribute to more global forms of mis-estimation was obtained, by virtue of correlations between poorer global accuracy scores and greater mis-estimation of interpersonal and vocational performance. Further, metacognitive monitoring as measured by the adapted WCST did account for a small but still significant proportion of the variance in real world outcomes. Specifically, metacognitive performance predicted social outcomes and to (a lesser degree) everyday activities, while not reaching significance for vocational outcomes. Thus, metacognitive monitoring represents a correlate of more global self assessment deficits and a significant contributor to real world functioning and a possible treatment target.

It is important to note that the data used in the current study was obtained using high contact clinician informants and not just self-report. There is now substantial data, including the present analyses, to indicate that self-assessment of cognitive performance and everyday functioning is fallible in patients with schizophrenia (e.g., Green et al., 2011; McKibbin et al., 2004; Bowie et al., 2007; Durand et al., in press, Sabbag et al., 2011). However, it is understood that high contact clinician informants are not always available in clinical settings and not all patients can complete comprehensive batteries such as those employed in the present study. However, a substantial proportion of patients clearly have someone who is in a position to provide an accurate estimation of their functioning. Several large scale studies prior to the present one, including several treatment studies, have collected 200 schizophrenia patients with an available informant (Bowie et al., 2008; Harvey, Ogasa, et al., 2011; Harvey, Raykov, et al., 2011; Keefe et al., 2011).

There are several other limitations worthy of mention. In this research it is impossible to define and calculate the range of functioning that would be considered within the normal range. We were only able to measure discrepancies and use clinician evaluations as the reference for accuracy. Another important limitation of the present research was that social cognition measures were not employed. Past research (Pinkham et al., 2006; Fett et al., 2011) has found that performance on social cognitive tasks predicts substantially more variance in social outcomes than do neurocognitive factors. Mis-estimation of functioning predicted social outcomes in the current sample, but it did so to a lesser extent than it predicted vocational and everyday activities. Subsequent comprehensive investigations of social functioning and specific interpersonal skills should incorporate social cognitive measures, which are currently being evaluated for their validity with a process similar to MATRICS and VALERO (Pinkham, et al., 2014).

The results indicated that psychological interventions and treatments are needed that not only target insight on a contemporaneous basis but also to more specifically increase patients’ ability to judge their functioning on a more global level. The current research indicates that this might hold promise for enhancing real world outcomes. Specifically, psychotherapy interventions incorporating insight-focused treatments are called for based on our results. This has also been suggested following previous investigations into metacognition and insight by Lysaker et al. (e.g., 2011a; 2011b; 2013; & 2014) and others (i.e., Hasson-Ohayon, 2009). Finally, based on the added contribution of momentary monitoring skills observed in the present study, cognitive retraining interventions aimed at improving one’s ability to function and make quick and accurate self-appraisals “in the moment” may also hold promise.

Acknowledgments

This research was supported by Grants MH078775 to Dr. Harvey and MH078737 to Dr. Patterson from the National Institute of Mental Health.

Footnotes

None of the other authors have any commercial interests to report.

References

  1. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, Gorman JM. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Archives of General Psychiatry. 1994;51(10):826–836. doi: 10.1001/archpsyc.1994.03950100074007. [DOI] [PubMed] [Google Scholar]
  2. Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. Assessment of insight in psychosis. American Journal of Psychiatry. 1993;150(6):873–879. doi: 10.1176/ajp.150.6.873. [DOI] [PubMed] [Google Scholar]
  3. Beck AT, Baruch E, Balter JM, Steer RA, Warman DM. A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophrenia Research. 2004;68(2-3):319–329. doi: 10.1016/S0920-9964(03)00189-0. doi: 10.1016/s0920-9964(03)00189-0. [DOI] [PubMed] [Google Scholar]
  4. Beck AT, Steer RA, Brown G. BDI-II: The Beck Depression Inventory. The Psychological Corporation; San Antonio, TX: 1996. [Google Scholar]
  5. Bowie CR, Leung WW, Reichenberg A, McClure MM, Patterson TL, Heaton RK, Harvey PD. Predicting schizophrenia patients’ real-world behavior with specific neuropsychological and functional capacity measures. Biological Psychiatry. 2008;63(5):505–511. doi: 10.1016/j.biopsych.2007.05.022. doi: 10.1016/j.biopsych.2007.05.022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bowie CR, Reichenberg A, Patterson TL, Heaton RK, Harvey PD. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. American Journal of Psychiatry. 2006;163(3):418–425. doi: 10.1176/appi.ajp.163.3.418. doi: 10.1176/appi.ajp.163.3.418. [DOI] [PubMed] [Google Scholar]
  7. Bowie CR, Twamley EW, Anderson H, Halpern B, Patterson TL, Harvey PD. Self-assessment of functional status in schizophrenia. Journal of Psychiatric Research. 2007;41(12):1012–1018. doi: 10.1016/j.jpsychires.2006.08.003. doi: 10.1016/j.jpsychires.2006.08.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brune M, Dimaggio G, Lysaker PH. Metacognition and social functioning in schizophrenia: Evidence, mechanisms of influence and treatment implications. Current Psychiatry Reviews. 2011;7(3):239–247. [Google Scholar]
  9. Carone DA, Benedict RH, Munschauer FE, 3rd, Fishman I, Weinstock-Guttman B. Interpreting patient/informant discrepancies of reported cognitive symptoms in MS. Journal of the International Neuropsychological Society. 2005;11(5):574–583. doi: 10.1017/S135561770505068X. doi: 10.1017/s135561770505068x. [DOI] [PubMed] [Google Scholar]
  10. Durand D, Strassnig M, Sabbag S, Gould F, Twamley EW, Patterson PT, Harvey PD. Factors Influencing Self-Assessment of Cognition and Functioning in Schizophrenia: Implications for Treatment Studies. European Neuropsychopharmacology. 2014 doi: 10.1016/j.euroneuro.2014.07.008. DOI: 10.1016/j.euroneuro.2014.07.008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fett AK, Viechtbauer W, Dominguez MD, Penn DL, van Os J, Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neuroscience and Biobehavioral Reviews. 2011;35(3):573–588. doi: 10.1016/j.neubiorev.2010.07.001. doi: 10.1016/j.neubiorev.2010.07.001. [DOI] [PubMed] [Google Scholar]
  12. Gould F, Bowie CR, Harvey PD. The influence of demographic factors on functional capacity and everyday functional outcomes in schizophrenia. Journal of Clinical and Experimental Neuropsychology. 2012;34(5):467–475. doi: 10.1080/13803395.2011.651102. doi: 10.1080/13803395.2011.651102. [DOI] [PubMed] [Google Scholar]
  13. Green MF, Schooler NR, Kern RS, Frese FJ, Granberry W, Harvey PD, Marder SR. Evaluation of functionally meaningful measuresD for clinical trials of cognition enhancement in schizophrenia. American Journal of Psychiatry. 2011;168(4):400–407. doi: 10.1176/appi.ajp.2010.10030414. doi: 10.1176/appi.ajp.2010.10030414. [DOI] [PubMed] [Google Scholar]
  14. Harvey PD, Raykov T, Twamley EW, Vella L, Heaton RK, Patterson TL. Validating the measurement of real-world functional outcomes: phase I results of the VALERO study. American Journal of Psychiatry. 2011;168(11):1195–1201. doi: 10.1176/appi.ajp.2011.10121723. doi: 10.1176/appi.ajp.2011.10121723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Harvey PD, Velligan DI, Bellack AS. Performance-based measures of functional skills: usefulness in clinical treatment studies. Schizophrenia Bulletin. 2007;33(5):1138–1148. doi: 10.1093/schbul/sbm040. doi: 10.1093/schbul/sbm040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Harvey Philip D., Ogasa M, Cucchiaro J, Loebel A, Keefe RSE. Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone. Schizophrenia Research. 2011;127(1):188–194. doi: 10.1016/j.schres.2011.01.004. doi: 10.1016/j.schres.2011.01.004. [DOI] [PubMed] [Google Scholar]
  17. Hasson-Ohayon I, Kravetz S, Levy I, Roe D. Metacognitive and interpersonal interventions for persons with severe mental illness: theory and practice. Israeli Journal of Psychiatry and Related Sciences. 2009;46(2):141–148. [PubMed] [Google Scholar]
  18. Johnson I, Tabbane K, Dellagi L, Kebir O. Self-perceived cognitive functioning does not correlate with objective measures of cognition in schizophrenia. Comprehensive Psychiatry. 2011;52(6):688–692. doi: 10.1016/j.comppsych.2010.12.008. doi: 10.1016/j.comppsych.2010.12.008. [DOI] [PubMed] [Google Scholar]
  19. Kay SR. Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison. Psychiatric Quarterly. 1990;61(3):163–178. doi: 10.1007/BF01064966. [DOI] [PubMed] [Google Scholar]
  20. Keefe RS, Fox KH, Harvey PD, Cucchiaro J, Siu C, Loebel A. Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial. Schizophrenia Research. 2011;125(2-3):161–168. doi: 10.1016/j.schres.2010.09.015. doi: 10.1016/j.schres.2010.09.015. [DOI] [PubMed] [Google Scholar]
  21. Kleinman L, Lieberman J, Dube S, Mohs R, Zhao Y, Kinon B, Revicki DA. Development and psychometric performance of the schizophrenia objective functioning instrument: an interviewer administered measure of function. Schizophrenia Research. 2009;107(2-3):275–285. doi: 10.1016/j.schres.2008.10.002. doi: 10.1016/j.schres.2008.10.002. [DOI] [PubMed] [Google Scholar]
  22. Koren D, Seidman LJ, Goldsmith M, Harvey PD. Real-world cognitive--and metacognitive--dysfunction in schizophrenia: a new approach for measuring (and remediating) more “right stuff”. Schizophrenia Bulletin. 2006;32(2):310–326. doi: 10.1093/schbul/sbj035. doi: 10.1093/schbul/sbj035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Koren D, Seidman LJ, Poyurovsky M, Goldsmith M, Viksman P, Zichel S, Klein E. The neuropsychological basis of insight in first-episode schizophrenia: a pilot metacognitive study. Schizophrenia Research. 2004;70(2-3):195–202. doi: 10.1016/j.schres.2004.02.004. doi: 10.1016/j.schres.2004.02.004. [DOI] [PubMed] [Google Scholar]
  24. Leifker FR, Patterson TL, Heaton RK, Harvey PD. Validating measures of real-world outcome: the results of the VALERO expert survey and RAND panel. Schizophrenia Bulletin. 2011;37(2):334–343. doi: 10.1093/schbul/sbp044. doi: 10.1093/schbul/sbp044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Leung WW, Bowie CR, Harvey PD. Functional implications of neuropsychological normality and symptom remission in older outpatients diagnosed with schizophrenia: A cross-sectional study. Journal of the International Neuropsychological Society. 2008;14(3):479–488. doi: 10.1017/S1355617708080600. doi: 10.1017/s1355617708080600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Lysaker PH, Dimaggio G. Metacognitive Capacities for reflection in Schizophrenia: Implications for Developing Treatments. Schizophrenia Bulletin. 2014;40 doi: 10.1093/schbul/sbu038. doi: 10.1093/schbul/sbu038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Lysaker PH, Dimaggio G, Buck KD, Callaway SS, Salvatore G, Carcione A, Stanghellini G. Poor insight in schizophrenia: links between different forms of metacognition with awareness of symptoms, treatment need, and consequences of illness. Comprehensive Psychiatry. 2011;52(3):253–260. doi: 10.1016/j.comppsych.2010.07.007. doi: 10.1016/j.comppsych.2010.07.007. [DOI] [PubMed] [Google Scholar]
  28. Lysaker PH, Gumley A, Luedtke B, Buck KD, Ringer JM, Olesek K, Dimaggio G. Social cognition and metacognition in schizophrenia: evidence of their independence and linkage with outcomes. Acta Psychiatrica Scandinavia. 2013;127(3):239–247. doi: 10.1111/acps.12012. doi: 10.1111/acps.12012. [DOI] [PubMed] [Google Scholar]
  29. Mausbach BT, Harvey PD, Goldman SR, Jeste DV, Patterson TL. Development of a brief scale of everyday functioning in persons with serious mental illness. Schizophrenia Bulletin. 2007;33(6):1364–1372. doi: 10.1093/schbul/sbm014. doi: 10.1093/schbul/sbm014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. McKibbin C, Patterson TL, Jeste DV. Assessing disability in older patients with schizophrenia: results from the WHODAS-II. Journal of Nervous and Mental Disease. 2004;192(6):405–413. doi: 10.1097/01.nmd.0000130133.32276.83. [DOI] [PubMed] [Google Scholar]
  31. Medalia A, Thysen J. Insight into neurocognitive dysfunction in schizophrenia. Schizophrenia Bulletin. 2008;34(6):1221–1230. doi: 10.1093/schbul/sbm144. doi: 10.1093/schbul/sbm144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Medalia A, Thysen J. A comparison of insight into clinical symptoms versus insight into neuro-cognitive symptoms in schizophrenia. Schizophrenia Research. 2010;118(1-3):134–139. doi: 10.1016/j.schres.2009.09.027. doi: 10.1016/j.schres.2009.09.027. [DOI] [PubMed] [Google Scholar]
  33. Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Marder SR. The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. American Journal of Psychiatry. 2008;165(2):203–213. doi: 10.1176/appi.ajp.2007.07010042. doi: 10.1176/appi.ajp.2007.07010042. [DOI] [PubMed] [Google Scholar]
  34. Patterson TL, Semple SJ, Shaw WS, Halpain M, Moscona S, Grant I, Jeste DV. Self-reported social functioning among older patients with schizophrenia. Schizophrenia Research. 1997;27(2-3):199–210. doi: 10.1016/S0920-9964(97)00078-9. doi: 10.1016/s0920-9964(97)00078-9. [DOI] [PubMed] [Google Scholar]
  35. Pinkman AE, Penn DL, Green HF, Buck B, Healy K, Harvey PD. The Social Cognition Psychometric Evaluation (SCOPE) Study: Results of the Expert Survey and RAND Panel. Schizophrenia Bulletin. 2014;40:813–823. doi: 10.1093/schbul/sbt081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Pinkham AE, Penn DL. Neurocognitive and social cognitive predictors of interpersonal skill in schizophrenia. Psychiatry Res. 2006;143(2-3):167–178. doi: 10.1016/j.psychres.2005.09.005. doi: 10.1016/j.psychres.2005.09.005. [DOI] [PubMed] [Google Scholar]
  37. Sabbag S, Twamley EM, Vella L, Heaton RK, Patterson TL, Harvey PD. Assessing everyday functioning in schizophrenia: not all informants seem equally informative. Schizophrenia Research. 2011;131(1-3):250–255. doi: 10.1016/j.schres.2011.05.003. doi: 10.1016/j.schres.2011.05.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Schneider LC, Struening EL. SLOF: a behavioral rating scale for assessing the mentally ill. Social Work Research and Abstracts. 1983;19(3):9–21. doi: 10.1093/swra/19.3.9. [DOI] [PubMed] [Google Scholar]
  39. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry. 1998;59(Suppl 20):22–33. quiz 34-57. [PubMed] [Google Scholar]
  40. Simon V, De Hert M, Wampers M, Peuskens J, van Winkel R. The relation between neurocognitive dysfunction and impaired insight in patients with schizophrenia. European Psychiatry. 2009;24(4):239–243. doi: 10.1016/j.eurpsy.2008.10.004. doi: 10.1016/j.eurpsy.2008.10.004. [DOI] [PubMed] [Google Scholar]
  41. Spikman JM, van der Naalt J. Indices of impaired self-awareness in traumatic brain injury patients with focal frontal lesions and executive deficits: implications for outcome measurement. Journal of Neurotrauma. 2010;27(7):1195–1202. doi: 10.1089/neu.2010.1277. doi: 10.1089/neu.2010.1277. [DOI] [PubMed] [Google Scholar]
  42. Ventura J, Reise SP, Keefe RS, Hurford IM, Wood RC, Bilder RM. The Cognitive Assessment Interview (CAI): reliability and validity of a brief interview-based measure of cognition. Schizophrenia Bulletin. 2013;39(3):583–591. doi: 10.1093/schbul/sbs001. doi: 10.1093/schbul/sbs001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Ventura J, Wood RC, Jimenez AM, Hellemann GS. Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: meta-analytic findings. Schizophrenia Research. 2013;151(1-3):78–84. doi: 10.1016/j.schres.2013.10.015. doi: 10.1016/j.schres.2013.10.015. [DOI] [PMC free article] [PubMed] [Google Scholar]

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