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NIHPA Author Manuscripts logoLink to NIHPA Author Manuscripts
. Author manuscript; available in PMC: 2015 Aug 6.
Published in final edited form as: Nature. 2015 Jun 10;523(7560):370. doi: 10.1038/nature14551

Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Madhu S Kumar, Elena Armenteros-Monterroso, Philip East, Probir Chakravorty, Nik Matthews, Monte M Winslow, Julian Downward
PMCID: PMC4527149  NIHMSID: NIHMS712621  PMID: 26061768

In this Letter, we reported that Hmga2 promotes lung cancer progression in mouse and human cells by operating as a competing endogenous RNA for the let-7 microRNA family. It has been brought to our attention that the cell lines used in the RNA sequencing (RNA-seq) experiment presented in Extended Data Fig. 4 of the Letter cannot be those specified in the figure legend. Moreover, these data cannot generate the Sylamer plots presented in this figure. The cell line substitution also casts doubt on which cells were used for experiments presented elsewhere in the paper. Although replication of other experiments in the Letter have not uncovered any further inconsistencies, given this uncertainty and the clear issues with Extended Data Fig. 4, we think it prudent to retract the paper pending more thorough investigation. We apologize for any adverse consequences that this may have caused.

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