In this Letter, we reported that Hmga2 promotes lung cancer progression in mouse and human cells by operating as a competing endogenous RNA for the let-7 microRNA family. It has been brought to our attention that the cell lines used in the RNA sequencing (RNA-seq) experiment presented in Extended Data Fig. 4 of the Letter cannot be those specified in the figure legend. Moreover, these data cannot generate the Sylamer plots presented in this figure. The cell line substitution also casts doubt on which cells were used for experiments presented elsewhere in the paper. Although replication of other experiments in the Letter have not uncovered any further inconsistencies, given this uncertainty and the clear issues with Extended Data Fig. 4, we think it prudent to retract the paper pending more thorough investigation. We apologize for any adverse consequences that this may have caused.
. Author manuscript; available in PMC: 2015 Aug 6.
Published in final edited form as: Nature. 2015 Jun 10;523(7560):370. doi: 10.1038/nature14551
Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
Madhu S Kumar
, Elena Armenteros-Monterroso
, Philip East
, Probir Chakravorty
, Nik Matthews
, Monte M Winslow
, Julian Downward
Madhu S Kumar
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Elena Armenteros-Monterroso
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Philip East
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Probir Chakravorty
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Nik Matthews
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Monte M Winslow
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Julian Downward
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Issue date 2015 Jul 16.
PMCID: PMC4527149 NIHMSID: NIHMS712621 PMID: 26061768
The publisher's version of this retraction is available at Nature
This retracts the article "Hmga2 functions as a competing endogenous RNA to promote lung cancer progression" in volume 505, 10.1038/nature12785.