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. Author manuscript; available in PMC: 2016 Jul 3.
Published in final edited form as: Science. 2015 Jul 3;349(6243):62–66. doi: 10.1126/science.aab3753

Fig. 3. Diversification of pharmaceutical agents.

Fig. 3

Conditions: a. 5 mol % Cu(OAc)2, 5.5 mol % (S)-DTBM-SEGPHOS, (MeO)2MeSiH, internal olefin, THF, 45 °C. b. (R)-DTBM-SEGPHOS was used instead of (S)-DTBM-SEGPHOS. TFP = 2-(5-trifluoromethyl)pyridyl.