Table 2.
Function Categories Affected by TNF-alpha vs Control
Effect of TNFα vs Controls on targeted pathways using DAVID functional annotation statistical program. Gene-annotation enrichment analysis, functional annotation clustering on statistically differentially expressed genes. Statistical DAVID genes were analyzed for annotation cluster enrichment scores. The data represent the score, number of genes, shift direction and p-values (Fisher Exact/EASE Score).
| Annotation Cluster 1 | Enrichment Score: 7.62 | Count | P_Value | Benjamini | |
|---|---|---|---|---|---|
| GOTERM_BP_FAT | regulation of cytokine biosynthetic process | RT | 6 | 2.50E-10 | 1.40E-08 |
| Annotation Cluster 2 | Enrichment Score: 7.02 | Count | P_Value | Benjamini | |
| GOTERM_BP_FAT | positive regulation of protein kinase cascade | RT | 7 | 5.10E-12 | 8.5E-10 |
| GOTERM_BP_FAT | regulation of interleukin-6 production | RT | 6 | 6.5E-12 | 8.10E-10 |
| GOTERM_BP_FAT | positive regulation of I-kappaB kinase/NF-kappaB cascade | RT | 6 | 7.7E-12 | 7.70E-10 |
| GOTERM_BP_FAT | regulation of stress-activated protein kinase signaling pathway | RT | 5 | 1.40E-08 | 4.20E-07 |
| Annotation Cluster 3 | Enrichment Score: 4.08 | Count | P_Value | Benjamini | |
| GOTERM_BP_FAT | regulation of chemokine product | RT | 4 | 3.30E-08 | 8.60E-07 |