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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Neuropharmacology. 2014 Nov 11;90:23–32. doi: 10.1016/j.neuropharm.2014.10.029

Figure 6.

Figure 6

Inhibiting NE β-receptors decreased but did not prevent MPH’s effect. (A) Systemic injection of a non-specific NE β-receptor antagonist, timolol, alone did not affect synaptic transmission following the weak TBS (n = 5). (B) Saline administered before MPH and TBS (black, n = 5) gave robust LTP, while timolol administered before MPH and TBS (grey, n = 7) decreased MPH’s effect on the resulting synaptic transmission, but LTP was not blocked. Treatments were counterbalanced and given at least 7 days apart for each mouse. Injection of timolol before the MPH/TBS LTP induction protocol significantly decreased the resulting synaptic transmission in the dentate gyrus when compared to the saline control, (F(1,339) = 252.4, p < 0.05).