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. 2015 May 1;2(6):536–543. doi: 10.1016/j.ebiom.2015.04.019

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Associations between placental gene expression and maternal U–As. Multivariable linear regression analyses were performed to determine the association between maternal U–As and placental gene expression. The analyses were adjusted for maternal age. GLI1/GLI1-2 and PTCH1/PTCH1-2 are sequence-distinct Nanostring probes designed to measure the expression of GLI1 and PTCH1. Dots depict coefficient estimates and error bars represent 95% CIs. Significant associations are those with 95% CIs not crossing zero (dotted line) and are marked by asterisks (*P < 0.05). Green; HH pathway-related genes, purple; NOTCH pathway-related genes, blue; WNT pathway-related genes, orange; stemness genes.