Table 1.

Structures and PLD inhibitory activities of analogues 6.

Compd	R	PLD1 IC50 (nM)[a]	PLD2 IC50 (nM)[a]	Fold PLD2 selective
6a	H	>30,000	>30,000	–
6b		3,100	440	7
6c		4,000	320	12.5
6d		19,000	2,050	9
6e		8,760	2,750	~3
6f		>20,000	2,540	~10
6g		8,260	890	9.2
6h		4,590	205	22
6i		8,100	1,780	4.5
6j		3,500	7,200	–
6k		2,650	80	30
6l		>30,000	360	>80
6m		24,000	850	28

^[a]IC₅₀ values were determined in triplicate.