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. 1994 Dec 6;91(25):11973–11977. doi: 10.1073/pnas.91.25.11973

The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast.

T Lithgow 1, T Junne 1, K Suda 1, S Gratzer 1, G Schatz 1
PMCID: PMC45358  PMID: 7991567

Abstract

We have cloned the gene encoding the protein Mas22p, which spans the outer membrane of yeast mitochondria. Cells that completely lack Mas22p are inviable. The plasmid-borne MAS22 gene suppresses several defects resulting from the deletion of one or more of the mitochondrial protein import receptors. Defects of Mas20p-deficient cells are explained by the reduced level of Mas22p in these mutants. Mas22p has one acidic domain in the cytosol and a second acidic domain in the mitochondrial intermembrane space. We suggest that these domains of Mas22p on either side of the outer membrane function as a relay system for transferring the basic targeting sequences of precursor proteins into the mitochondria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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