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. 2015 May 25;6(15):12997–13005. doi: 10.18632/oncotarget.4092

Figure 2. PTPRD is involved in the insulin signaling pathway.

Figure 2

A. HepG2 cells were transfected with pSG5 vector and with pSG5-h-PPARγ2 for 48 h. PPARγ2 overexpression (1.53 fold versus vector only) induces the overexpression of PTPRD and insulin receptor 1.31 and 1.78 fold versus vector only, respectively. B. HepG2 cells were transfected with shRNA for 48 h. PTPRD knockdown (0.67 fold versus vector only) induced down-regulation of the PPARγ2 and insulin receptor (0.74 and 0.86 fold versus vector only, respectively). Moreover, STAT3 was induced 1.17 fold versus vector only.