Figure 4.

D-serine inhibition of EPSCs occluded the ability of the NMDAR blocker AP5 to inhibit EPSCs. (a) Sample traces and (b, c) grouped data showing that D-serine significantly reduced ChR2-evoked EPSCs evoked at −70 mV (−27.9±6.0% vs baseline) and, importantly, occluded AP5 from producing any further decrease in EPSCs (n=6), suggesting that D-serine acted by inhibiting HA-NMDARs. F_{2, 10}=10.15, p=0.004, Friedman repeated-measures ANOVA on ranks, post hoc Holm–Sidak test *p<0.05 for baseline vs D-serine or baseline vs D-serine+AP5; NS, for D-serine vs D-serine+AP5. D-ser, D-serine.