Abstract
Based on the analysis of genomic DNA from single healthy animals of each of five primate species, nucleotide and predicted amino acid sequences of the infectious amyloid precursor gene of higher apes (Gorilla and Pan) and Old World (Macaca) and New World (Ateles, Saimiri) monkeys showed 95-99% homology to the human sequences, corresponding to their phylogenetic distance from humans. Two of 18 amino acids that differed from humans resulted from nucleotide changes at sites of mutations in humans with familial forms of spongiform encephalopathy (a deleted codon within the codon 51-91 region of 24 bp repeats and a substitution at codon 198). In each of the five animals, codon 129 specified methionine, the more common of the two polymorphic genotypes in humans. Because genotypic homology did not correlate with experimental transmission rates of human spongiform encephalopathy, primary structural similarity of the infectious amyloid precursor protein in humans and experimental primates may not be an important factor in disease transmissibility.
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- Brown P., Cervenáková L., Goldfarb L. G., McCombie W. R., Rubenstein R., Will R. G., Pocchiari M., Martinez-Lage J. F., Scalici C., Masullo C. Iatrogenic Creutzfeldt-Jakob disease: an example of the interplay between ancient genes and modern medicine. Neurology. 1994 Feb;44(2):291–293. doi: 10.1212/wnl.44.2.291. [DOI] [PubMed] [Google Scholar]
- Brown P., Gibbs C. J., Jr, Rodgers-Johnson P., Asher D. M., Sulima M. P., Bacote A., Goldfarb L. G., Gajdusek D. C. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol. 1994 May;35(5):513–529. doi: 10.1002/ana.410350504. [DOI] [PubMed] [Google Scholar]
- Collinge J., Palmer M. S., Dryden A. J. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet. 1991 Jun 15;337(8755):1441–1442. doi: 10.1016/0140-6736(91)93128-v. [DOI] [PubMed] [Google Scholar]
- Goldfarb L. G., Brown P., McCombie W. R., Goldgaber D., Swergold G. D., Wills P. R., Cervenakova L., Baron H., Gibbs C. J., Jr, Gajdusek D. C. Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10926–10930. doi: 10.1073/pnas.88.23.10926. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldfarb L. G., Petersen R. B., Tabaton M., Brown P., LeBlanc A. C., Montagna P., Cortelli P., Julien J., Vital C., Pendelbury W. W. Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism. Science. 1992 Oct 30;258(5083):806–808. doi: 10.1126/science.1439789. [DOI] [PubMed] [Google Scholar]
- Kretzschmar H. A., Stowring L. E., Westaway D., Stubblebine W. H., Prusiner S. B., Dearmond S. J. Molecular cloning of a human prion protein cDNA. DNA. 1986 Aug;5(4):315–324. doi: 10.1089/dna.1986.5.315. [DOI] [PubMed] [Google Scholar]
- Kuppuswamy M. N., Hoffmann J. W., Kasper C. K., Spitzer S. G., Groce S. L., Bajaj S. P. Single nucleotide primer extension to detect genetic diseases: experimental application to hemophilia B (factor IX) and cystic fibrosis genes. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1143–1147. doi: 10.1073/pnas.88.4.1143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Palmer M. S., Dryden A. J., Hughes J. T., Collinge J. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature. 1991 Jul 25;352(6333):340–342. doi: 10.1038/352340a0. [DOI] [PubMed] [Google Scholar]
- Prusiner S. B. Transgenetic investigations of prion diseases of humans and animals. Philos Trans R Soc Lond B Biol Sci. 1993 Feb 27;339(1288):239–254. doi: 10.1098/rstb.1993.0022. [DOI] [PubMed] [Google Scholar]