Table 3. Patient characteristics (a) and their influence (b) in explaining the achievement of suppression at 6 months (through separate univariable logistic regressions).
(a) | |||||
---|---|---|---|---|---|
No history of injection drug use |
History of injection drug use |
||||
Achieved suppression at 6 months since HAART initiation | P value | ||||
|
|||||
Factors | No (N = 188) | Yes (N = 542) | No (N = 179) | Yes (N = 254) | |
Sex | |||||
Male | 163 (17%) | 487 (51%) | 129 (13%) | 186 (19%) | <0.0001 |
Female | 25 (13%) | 55 (28%) | 50 (25%) | 68 (34%) | |
HAART regimen | |||||
EFV-based | 70 (13%) | 269 (49%) | 76 (14%) | 134 (24%) | 0.0035 |
ATA/r-based | 118 (19%) | 273 (44%) | 103 (17%) | 120 (20%) | |
First year adherence to HAART | |||||
>95% | 134 (15%) | 470 (54%) | 77 (9%) | 197 (22%) | <0.0001 |
<95% | 54 (19%) | 72 (25%) | 102 (36%) | 57 (20%) | |
First year of HAART | |||||
2000–2004 | 26 (13%) | 83 (41%) | 39 (19%) | 54 (27%) | 0.0022 |
2005–2006 | 58 (16%) | 162 (44%) | 65 (17%) | 86 (23%) | |
2007–2009 | 104 (18%) | 297 (50%) | 75 (13%) | 114 (19%) | |
Age (years) | 44 (38–52) | 43 (36–51) | 42 (35–48) | 43 (37–49) | 0.0805 |
Baseline CD4 cell count (cells/μl) | 180 (80–260) | 215 (130–280) | 150 (90–220) | 185 (120–240) | <0.0001 |
Baseline viral load (log10 copies/ml) | 5.0 (4.9–5.0) | 4.9 (4.4–5.0) | 5.0 (4.7–5.0) | 4.9 (4.3–5.0) | <0.0001 |
(b) | |||
---|---|---|---|
Influence of each Factor on the achievement of suppression at 6 months since HAART initiation – AUC (rank) |
|||
Factors | Overall | No history of IDU | History of IDU |
History of injection drug use | 0.584 (4) | NA | NA |
Sex | 0.525 (6) | 0.516 (6) | 0.506 (7) |
HAART regimen | 0.554 (5) | 0.562 (4) | 0.551 (4) |
First year adherence to HAART | 0.632 (1) | 0.577 (3) | 0.673 (1) |
First year of HAART | 0.516 (7) | 0.509 (7) | 0.517 (6) |
Age (years) | 0.504 (8) | 0.534 (5) | 0.537 (5) |
Baseline CD4 cell count (cells/μl) | 0.592 (3) | 0.585 (2) | 0.583 (3) |
Baseline viral load (log10 copies/ml) | 0.627 (2) | 0.662 (1) | 0.592 (2) |
ATA/r, atazanavir boosted with 400 mg/day or less of ritonavir; AUC, area under the receiver operating curve; EFV, efavirenz.