Table 1. Antioxidants protect CASQ1-null mice from heat- and halothane-induced sudden deaths.

Number of mice (and experimental outcomes) tested during in-vivo heat challenge and halothane exposure. Whereas untreated CASQ1-null animals display a significant percentage of survival significantly lower compared to WT during both stress protocols (14% and 92% for heat stress; 21% and 100% for halothane exposure), pre-treatment with both NAC and Trolox bring back this percentage to values very close to those of WT (71% and 67% for heat stress; 75% and 80% for halothane exposure).

	HEAT				HALOTHANE
Responders	WT	CASQ1-null	NAC	Trolox	WT	CASQ1-null	NAC	Trolox
total tested	13	21	21	6	8	14	16	5
Survived	12	3	15	4	8	3	12	4
Sudden death	0	16	4	1	0	11	4	1
Delayed death	1	2	2	1	0	0	0	0
% Survived	92%	14%	71%	67%	100%	21%	75%	80%

CASQ1-null, calsequestrin 1 knock-out; NAC, N-accetylcysteine; WT, wild type.