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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Anesthesiology. 2015 Sep;123(3):603–617. doi: 10.1097/ALN.0000000000000748

Table 2. Antioxidants reduce hyperthermia during heat challenge in CASQ1-null mice.

Absolute and relative changes in core temperature measured at the beginning (t0) and end (t60) of the experiments. The increase in core temperature, during heat challenge, was significantly higher in CASQ1-null mice respect to WT animals (6.4±0.3 vs 4.7±0.3 respectively). However, we observed significant reduction of ΔT in CASQ1-null mice treated with NAC and Trolox (5.3±0.2 a 4.8±0.2 respectively).

Wild type
n=6		 CASQ1-null
n=10		 CASQ1-null (NAC)
n=7		 CASQ1-null (Trolox)
n=6
t0 35.4 ± 0.3 35.9 ± 0.2 35.3 ± 0.2 35.8 ± 0.3
t60 40.1 ± 0.1 42.3 ± 0.1 40.6 ± 0.3 40.5 ± 0.3
ΔT 4.7 ± 0.3 6.4 ± 0.3 5.3 ± 0.2 4.8 ± 0.2

CASQ1-null, calsequestrin 1 knock-out; ΔT, relative temperature; NAC, N-acetylcysteine; WT, wild type.