Table 2. Antioxidants reduce hyperthermia during heat challenge in CASQ1-null mice.
Wild type n=6 |
CASQ1-null n=10 |
CASQ1-null (NAC) n=7 |
CASQ1-null (Trolox) n=6 |
|
---|---|---|---|---|
t0 | 35.4 ± 0.3 | 35.9 ± 0.2 | 35.3 ± 0.2 | 35.8 ± 0.3 |
t60 | 40.1 ± 0.1 | 42.3 ± 0.1 | 40.6 ± 0.3 | 40.5 ± 0.3 |
ΔT | 4.7 ± 0.3 | 6.4 ± 0.3 | 5.3 ± 0.2 | 4.8 ± 0.2 |
CASQ1-null, calsequestrin 1 knock-out; ΔT, relative temperature; NAC, N-acetylcysteine; WT, wild type.