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. 1988 Mar;7(3):691–695. doi: 10.1002/j.1460-2075.1988.tb02864.x

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

D G Wilkinson 1, G Peters 1, C Dickson 1, A P McMahon 1
PMCID: PMC454374  PMID: 3293998

Abstract

The proto-oncogene int-2 has been implicated in the formation of mouse mammary-tumour-virus-induced mammary tumours. Analysis of the predicted coding sequence indicates that int-2 is a member of the fibroblast growth factor family. Previous studies using Northern blot analysis suggested that normal expression of int-2 may be confined to extra-embryonic endoderm lineages of embryonic stages of mouse development. We have used in situ hybridization and Northern blot analysis to examine directly int-2 expression in embryo stem cells and in the developing embryo from early gastrulation to midsomite stages. Complex patterns of accumulation of int-2 RNA were observed in embryonic and extra-embryonic tissues. The data suggest multiple roles for int-2 in development which may include migration of early mesoderm cells and induction of the otocyst.

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Selected References

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