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. 2015 Apr 20;6(16):14290–14299. doi: 10.18632/oncotarget.3742

Figure 1. Increased expression levels of Dtx3l in melanoma tissues and cells in mice.

Figure 1

Expression levels (means ± SD) of Dtx3l transcript A. in benign melanocytic tumors (lane 1; n = 4) and melanomas (lane 2; n = 4) from RET-mice by real-time PCR analysis are presented. Representative results for Dtx3l protein expression in benign tumors (lanes 1 and 2 in B, lane 1 in C) and melanomas (lanes 3 and 4 in B, lane 2 in C) from RET-mice by immunoblot B. and immunohistochemical C. analyses are presented. Expression levels of Dtx3l (means ± SD) determined by densitometric analyses of the bands in 3 independent experiments are presented as graphs showing relative intensities (lanes 2–4 in B) for a benign tumor (lane 1 in B). Expression levels of Dtx3l protein D. in B16 (lane 1), B16F1 (lane 2), B16F10 (lane 3) and B16BL6 (lane 4) melanoma cells determined by immunoblot analysis are presented. Expression levels of Dtx3l (means ± SD) determined by densitometric analyses of the bands in 3 independent experiments are presented as graphs showing relative intensities (lanes 2–4 in D) for B16 (lane 1 in D). Expression levels of α-Tubulin are presented as an internal control (B, D). *, Significantly different (*, p < 0.05; **, p < 0.01) by Dunnett's test. Scale bar, 200 μM.