Fig. 10.

Concentration–response curves for the wild-type and mutated α7 nAChRs. Data are shown from wild-type α7 nAChRs (A), α7 nAChRs containing the L247T (9′) mutation (B) and α7 nAChRs containing the M260L (22′) mutation (C). Data are presented for a range of concentrations of acetylcholine (circles), the allosteric agonist 4BP-TQS (hexagons), the type II PAMs, TQS (squares) and TBS-516 (inverted triangles), and the type I PAMs, NS-1738 (triangles) and TBS-346 (diamonds). Data are means ± SEM of at least three independent experiments and are normalised to the maximum acetylcholine response.