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. 1988 Dec 1;7(12):3737–3743. doi: 10.1002/j.1460-2075.1988.tb03257.x

A new type of transforming growth factor-beta, TGF-beta 3.

R Derynck 1, P B Lindquist 1, A Lee 1, D Wen 1, J Tamm 1, J L Graycar 1, L Rhee 1, A J Mason 1, D A Miller 1, R J Coffey 1, et al.
PMCID: PMC454948  PMID: 3208746

Abstract

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

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Selected References

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