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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Leukemia. 2015 Feb 24;29(7):1524–1529. doi: 10.1038/leu.2015.31

Table 5.

Pharmacokinetics of Dinaclib on Days 1 and 15 of Therapy

Day 1
Pharmacokinetics		 No
Pts		 Cmax
(ng/mL)		 AUC(I)
(ng·hr/mL)		 T1/2 (hr) CL (L/hr/m2) Vd (L/m2)
Dose Mean CV% Mean CV% Mean CV% Mean CV% Mean CV%
5 mg/m2 4 95.4 41 191 53 2.45 31 26.2 53 92.8 37
7 mg/m2 18 208 29 403 38 2.65 32 17.3 38 66.2 35
10 mg/m2 9 277 23 501 26 2.85 33 19.9 26 81.8 42
14 mg/m2 16 404 28 775 33 2.85 14 18.1 33 74.4 32
17 mg/m2 4 624 63 1290 88 2.93 6.6 13.2 88 55.9 79
Day 15 Pharmacokinetics
5 mg/m2 3 150 52 310 49 2.50 38 16.1 50 60.3 100
7 mg/m2 8 157 27 294 26 2.31 25 23.8 26 79.5 27
10 mg/m2 7 299 29 592 36 2.82 41 16.8 36 68.4 58
14 mg/m2 27 428 24 827 25 2.92 27 17 26 71.4 38
17 mg/m2 3 634 110 1260 140 2.95 15 13.8 140 58.9 110