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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Dec 20;91(26):12947–12951. doi: 10.1073/pnas.91.26.12947

Sleep patterns are disturbed in cats infected with feline immunodeficiency virus.

O Prospéro-García 1, N Herold 1, T R Phillips 1, J H Elder 1, F E Bloom 1, S J Henriksen 1
PMCID: PMC45557  PMID: 7809152

Abstract

Human immunodeficiency virus (HIV)-related sleep disturbances have been reported early in AIDS. Likewise, the feline immunodeficiency virus (FIV), a natural lentivirus pathogen of cats, produces a similar immunodeficiency syndrome with neurological sequelae. To identify the neurophysiological substrate of FIV infection in brain, pathogen-free cats were infected with the Maryland strain of FIV. Eight weeks after inoculation, all FIV-infected cats seroconverted and virus was detected in the cerebrospinal fluid and in the mononuclear cells of peripheral blood. Ten to 12 months after the FIV inoculation, inoculated and control cats were surgically implanted with electrodes to record the sleep/wake cycle. These sleep recordings were obtained under conditions controlling for environmental variables and instrumental adaptation. FIV-infected cats spent 50% more time awake than the sham-inoculated controls and exhibited many more sleep/waking stage shifts--i.e., 40% more than controls. In addition, FIV-infected cats showed approximately 30% of rapid eye movement (REM) sleep reduction compared to controls. The latency to sleep and REM sleep onset was also significantly delayed in FIV-infected cats. In addition, a remarkable increase in cortically recorded spindle activity (8-13 Hz) was observed during slow-wave sleep in some infected subjects, similar to changes described in HIV-infected humans. Moreover, infected cats exhibited no overt signs of systemic morbidity, such as hyperpyrexia or body weight loss. These results indicate that FIV-infected cats exhibit sleep abnormalities similar to the sleep disturbances previously described in AIDS patients and further support the feline preparation as a valuable animal model of HIV infection of the central nervous system.

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Selected References

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  1. Benveniste E. N. Cytokine circuits in brain. Implications for AIDS dementia complex. Res Publ Assoc Res Nerv Ment Dis. 1994;72:71–88. [PubMed] [Google Scholar]
  2. Bracci L., Lozzi L., Rustici M., Neri P. Binding of HIV-1 gp120 to the nicotinic receptor. FEBS Lett. 1992 Oct 19;311(2):115–118. doi: 10.1016/0014-5793(92)81380-5. [DOI] [PubMed] [Google Scholar]
  3. Darko D. F., McCutchan J. A., Kripke D. F., Gillin J. C., Golshan S. Fatigue, sleep disturbance, disability, and indices of progression of HIV infection. Am J Psychiatry. 1992 Apr;149(4):514–520. doi: 10.1176/ajp.149.4.514. [DOI] [PubMed] [Google Scholar]
  4. Davis L. E., Hjelle B. L., Miller V. E., Palmer D. L., Llewellyn A. L., Merlin T. L., Young S. A., Mills R. G., Wachsman W., Wiley C. A. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology. 1992 Sep;42(9):1736–1739. doi: 10.1212/wnl.42.9.1736. [DOI] [PubMed] [Google Scholar]
  5. Heyes M. P., Rubinow D., Lane C., Markey S. P. Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Ann Neurol. 1989 Aug;26(2):275–277. doi: 10.1002/ana.410260215. [DOI] [PubMed] [Google Scholar]
  6. Hopper C. D., Sparkes A. H., Gruffydd-Jones T. J., Crispin S. M., Muir P., Harbour D. A., Stokes C. R. Clinical and laboratory findings in cats infected with feline immunodeficiency virus. Vet Rec. 1989 Sep 23;125(13):341–346. doi: 10.1136/vr.125.13.341. [DOI] [PubMed] [Google Scholar]
  7. Hurtrel M., Ganière J. P., Guelfi J. F., Chakrabarti L., Maire M. A., Gray F., Montagnier L., Hurtrel B. Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS. 1992 Apr;6(4):399–406. doi: 10.1097/00002030-199204000-00007. [DOI] [PubMed] [Google Scholar]
  8. Jordan E. K., Heyes M. P. Virus isolation and quinolinic acid in primary and chronic simian immunodeficiency virus infection. AIDS. 1993 Sep;7(9):1173–1179. doi: 10.1097/00002030-199309000-00004. [DOI] [PubMed] [Google Scholar]
  9. Lipton S. A. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends Neurosci. 1992 Mar;15(3):75–79. doi: 10.1016/0166-2236(92)90013-x. [DOI] [PubMed] [Google Scholar]
  10. Miller E. N., Selnes O. A., McArthur J. C., Satz P., Becker J. T., Cohen B. A., Sheridan K., Machado A. M., Van Gorp W. G., Visscher B. Neuropsychological performance in HIV-1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS) Neurology. 1990 Feb;40(2):197–203. doi: 10.1212/wnl.40.2.197. [DOI] [PubMed] [Google Scholar]
  11. Miyazawa T., Mikami T. Biological nature of feline immunodeficiency virus. J Vet Med Sci. 1993 Aug;55(4):519–526. doi: 10.1292/jvms.55.519. [DOI] [PubMed] [Google Scholar]
  12. Miyazawa T., Tomonaga K., Kawaguchi Y., Mikami T. The genome of feline immunodeficiency virus. Arch Virol. 1994;134(3-4):221–234. doi: 10.1007/BF01310563. [DOI] [PubMed] [Google Scholar]
  13. Norman S. E., Chediak A. D., Kiel M., Cohn M. A. Sleep disturbances in HIV-infected homosexual men. AIDS. 1990 Aug;4(8):775–781. doi: 10.1097/00002030-199008000-00009. [DOI] [PubMed] [Google Scholar]
  14. Phillips T. R., Prospero-Garcia O., Puaoi D. L., Lerner D. L., Fox H. S., Olmsted R. A., Bloom F. E., Henriksen S. J., Elder J. H. Neurological abnormalities associated with feline immunodeficiency virus infection. J Gen Virol. 1994 May;75(Pt 5):979–987. doi: 10.1099/0022-1317-75-5-979. [DOI] [PubMed] [Google Scholar]
  15. Pierelli F., Soldati G., Zambardi P., Garrubba C., Spadaro M., Tilia G., Pauri F., Morocutti C. Electrophysiological study (VEP, BAEP) in HIV-1 seropositive patients with and without AIDS. Acta Neurol Belg. 1993;93(2):78–87. [PubMed] [Google Scholar]
  16. Podell M., Oglesbee M., Mathes L., Krakowka S., Olmstead R., Lafrado L. AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection. J Acquir Immune Defic Syndr. 1993 Jul;6(7):758–771. [PubMed] [Google Scholar]
  17. Prospéro-García O., Herold N., Waters A. K., Phillips T. R., Elder J. H., Henriksen S. J. Intraventricular administration of a FIV-envelope protein induces sleep architecture changes in rats. Brain Res. 1994 Oct 3;659(1-2):254–258. doi: 10.1016/0006-8993(94)90888-5. [DOI] [PubMed] [Google Scholar]
  18. Talbott R. L., Sparger E. E., Lovelace K. M., Fitch W. M., Pedersen N. C., Luciw P. A., Elder J. H. Nucleotide sequence and genomic organization of feline immunodeficiency virus. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5743–5747. doi: 10.1073/pnas.86.15.5743. [DOI] [PMC free article] [PubMed] [Google Scholar]

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