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iPLA2-VIA−/− flies have reduced ATP levels and are more sensitive to oxidative stress. (A) ATP levels are reduced in the heads of Day 25 iPLA2-VIA−/− flies compared with age-matched w1118 control flies (*P < 0.05). (B) Aged Day 15 iPLA2-VIA−/− flies show reduced survival when treated with 5% hydrogen peroxide (H2O2) (P = 5.6 × 10−7) and (C) 20 mM paraquat (P = 4.6 × 10−7) compared with w1118 control flies (n = 150 flies per genotype).
