Editor-in-Chief
Piet van der Graaf, PhD, PharmD
Dr. van der Graaf is highly regarded in the areas of pharmacometrics and systems pharmacology as evident through his numerous publications, presentations, and committee memberships. He has a proven track record of innovation in both academic and industrial pharmaceutical research environments and holds several patents in the field of target discovery. He is currently the Director of the Leiden Academic Centre for Drug Research (LACDR) and Professor of Systems Pharmacology at Leiden University (The Netherlands). He received his doctorate training in quantitative pharmacology with Nobel laureate Sir James Black at King’s College London and worked as a postdoctoral fellow with Drs.Meindert Danhof and Douwe Breimer at Leiden University on the development of mechanism-based PKPD approaches. From 1999-2013, he held various scientific leadership roles at Pfizer UK in Discovery Biology, Pharmacokinetics and Drug Metabolism and Clinical Pharmacology/Pharmacometrics. As a member of the Quantitative and Systems Pharmacology Working Group, Dr. van der Graaf co-authored the 2011 NIH White Paper Quantitative and Systems Pharmacology in the Post-genomic Era: New Approaches to Discovering Drugs and Understanding Therapeutic Mechanisms. In 2012 he was elected as Fellow of the British Pharmacological Society.
Deputy Editor-in-Chief
Lena Friberg, PhD
Dr. Friberg is an Associate Professor in the Department of Pharmaceutical Biosciences at Uppsala University in Sweden. She holds a Masters in Pharmaceutical Sciences and a PhD from Uppsala University. Her research focuses on pharmacometrics and development of population pharmacokinetic and pharmacodynamic models for desired effects and adverse events in a range of therapeutic areas, such as oncology, bacterial infections, schizophrenia, rheumatoid arthritis, and QT prolongation. Currently, most of her research is focused on development of PKPD-models for quantitative, longitudinal predictions of use for translation of drug effects from preclinical (in vitro and in vivo) to patients and fromearly to late clinical development.
Associate Editors
Stephen Duffull, PhD
Stephen Duffull is a Professor of Clinical Pharmacy and Dean of the School of Pharmacy at the University of Otago, Dunedin, New Zealand. He runs a modeling and simulation lab within the School of Pharmacy. Research interests include optimal design, MCMC methods particularly in clinical toxicology and haemostasis. He has been involved in the area of PKPD and nonlinear mixed effects modeling for 20 years. Currently his research involves the development of pharmacological models, modeling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.
Douglas A. Lauffenburger, PhD
Dr. Lauffenburger is Ford Professor of Bioengineering and Head of the Department of Biological Engineering at MIT, and also holds appointments in the Department of Biology and the Department of Chemical Engineering. He is a member of the Koch Institute for Integrative Cancer Research, the Center for Biomedical Engineering, the Center for Environmental Health Sciences, and the Center for Gynepathology Research, and is Director of the Computational & Systems Biology Initiative. He earned BS and PhD degrees in chemical engineering from the University of Illinois and the University of Minnesota, in 1975 and 1979, respectively. His major research interests are in cell engineering: the fusion of engineering with molecular cell biology. Dr. Lauffenburger is a member of the National Academy of Engineering and of the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of AIMBE, and on the Advisory Council for the National Institute for General Medical Sciences at NIH.
Lang Li, PhD
Lang Li, PhD, is an Associate Professor in the Department of Medical and Molecular Genetics in the Indiana University School of Medicine (IUSM). He received his PhD in Biostatistics from the University of Michigan in Ann Arbor, Michigan, before joining the IUSM in 2001. Dr. Li is the Interim Director of the Center for Computational Biology and Bioinformatics in the IUSM, and the Associate Director of the Indiana Institute of Personalized Medicine (IIPM). He uses informatics, genomics and statistics to investigate drug efficacy and safety problems. He is interested in both the molecular mechanisms and clinical significance of drug safety and efficacy.
DonaldMager, PharmD, PhD
Dr. Mager is an Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB). He received his BS degree in Pharmacy from UB in 1991, followed by the PharmD (2000) and PhD (2002) degrees. Prior to joining the faculty at UB, he completed two years of postdoctoral training as an IRTA Fellow at the National Institute on Aging of the NIH, where he continued to serve as a special volunteer from 2004 to 2010. He received the University at Buffalo Young Investigator Award in 2006 and the New Investigator Award in Pharmacokinetics, Pharmacodynamics, and Drug Metabolism from AAPS in 2007. He currently serves on the Clinical Pharmacology Advisory Committee to the FDA and the Editorial Advisory Boards of Biopharmaceutics and Drug Disposition and Journal of Pharmacokinetics and Pharmacodynamics. He was also elected as a Fellow to the American College of Clinical Pharmacology, as Chair of the Clinical Pharmacology and Translational Research section of AAPS, and as a member of the Board of Directors to the International Society of Pharmacometrics. His research focuses on identifying molecular and physiological factors that control the pharmacological properties of various drugs including anti-cancer, immunomodulatory, and anti-platelet drugs.
France Mentré,MD, PhD
Dr. Mentré is a Professor of Biostatistics in the School of Medicine of University Paris Diderot (Paris 7). She heads an INSERM research team on Biostatistical Modelling and Pharmacometrics. She has worked on development and application of methods for nonlinear mixed-effects models in pharmacokinetics and pharmacodynamics for more than 25 years. She is involved in the development of the software PFIM for optimal design. Dr. Mentré has co-authored more than 150 articles in biostatistics, pharmacometrics, clinical pharmacology and medicine.
Amin Rostami-Hodjegan, PharmD, PhD
Dr. Rostami-Hodjegan is a Professor of Systems Pharmacology at the Centre for Applied Pharmacokinetic Research (CAPKR) in the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester. He has an active program of training PhD students in CAPKR in Systems Pharmacology and Pharmacokinetics, and numerous students graduated under his supervision from the University of Sheffield, where he was a Professor of Systems Pharmacology before joining the University of Manchester in 2009. As the Vice President of Research & Development at Simcyp Limited (a Certara Company), Dr. Rostami-Hodjegan leads a team of over 30 scientists working on extrapolation of in vitro data on drug metabolism to predict in vivo pharmacokinetics and pharmacodynamics in virtual patient populations. Professor Rostami-Hodjegan has authored/co-authored over 120 peer-reviewed full articles and serves on the Editorial Boards of several journals. He has been an invited speaker at over 100 national and international meetings and has led a number of hands-on workshops in the area of in vitro-in vivo extrapolation as applied to ADME in Drug Development
Paolo Vicini, PhD
Dr. Vicini is a Research Fellow in the Pharmacokinetics, Dynamics and Metabolism Department at Pfizer Worldwide Research and Development in San Diego, CA. He received his PhD in bioengineering from the Polytechnic of Milan in 1996. In 2003, he received the IEEE Engineering in Medicine and Biology Early Career Achievement Award. His previous research focus was on the development of data analysis software and the application of modeling and simulation to glucose and insulin metabolism, cancer, pharmacokinetics and pharmacodynamics. Since his move to Pfizer in 2008, his work has focused on translational modeling and simulation in support of various discovery programs. He has published more than 100 articles employing diverse modeling and simulation technology on a variety of applications.
Editorial Board
Sandra Allerheiligen, PhD
Merck Research Laboratories West Point, PA, USA
Ioannis Androulakis, PhD
Rutgers University Surgery, UMDNJ-RWJ Medical School
Piscataway Township, NJ, USA
Joseph P Balthasar, PhD
University of Buffalo Buffalo, NY, USA
JeffreyS. Barrett, PhD, FCP
The Children’s Hospital of Philadelphia Philadelphia, PA, USA
Robert Bies, PharmD, PhD
Indiana University Bloomington, IN, USA
Kim L. R. Brouwer, PharmD, PhD
University of North Carolina at Chapel Hill Chapel Hill, NC, USA
Jenny Chien, PhD
Eli Lilly & Co. Clinton, IN, USA
DavidZ. D’Argenio, PhD
University of Southern California Los Angeles, CA, USA
Oleg Demin, PhD
CSO Institute for Systems Biology SPb Moscow, Russia
Hartmut Derendorf, PhD
University of Florida Gainesville, FL, USA
JamesM. Gallo, PharmD,PhD
Mount Sinai School of Medicine New York, NY, USA
Christine Garnett, PhD
Certara St Louis,MO, USA
David Gavaghan, PhD
University of Oxford Oxford, United Kingdom
Ekaterina Gibiansky, PhD
QuantPharm LLC North Potomac,MD, USA
Bart Hendriks, PhD
Merrimack Pharmaceuticals Cambridge,MA, USA
Nicholas H.G. Holford, MBChB
The University of Auckland Auckland, New Zealand
Matt Hutmacher, PhD
Ann Arbor Pharmacometrics Group Ann Arbor,MI, USA
Ravi Iyengar, PhD
Mount Sinai School of Medicine New York, NY
Jin Yan Jin, PhD
Genentech, Inc San Francisco, CA, USA
Mats Olof Karlsson, PhD
Uppsala University Uppsala, Sweden
Terrence Kenakin, PhD
University of North Carolina, Chapel Hill Chapel Hill, NC, USA
Hiroaki Kitano, PhD
The Systems Biology Institute Tokyo, Japan
Charlotte Kloft, PhD
Freie Universitaet Berlin Berlin, Germany
Joerg Lippert, PhD
Bayer Healthcare Pharmaceuticals Leverkusen, Germany
Phil Lowe, PhD
Novartis Pharma AG Basel, Switzerland
Wei Lu, PhD
Peking University/Pfizer Pharmacometrics Beijing, China
EfthymiosManolis,MSc
EuropeanMedicines Agency London, United Kingdom
PeterMilligan, PhD
Pfizer Global Research and Development London, United Kindgdom
Diane R Mould, PhD, FCP
Projections Research Inc. Phoenixville, PA, USA
Jerry Nedelman, PhD
Novartis Pharmaceuticals Corporation East Hanover, NJ, USA
Kyungsoo Park,MD, PhD
Yonsei University College ofMedicine Seoul, Republic of Korea
Marc Pfister, MD, FCP
University of Basel Basel, Switzerland
Jose Pinheiro, PhD
Johnson and Johnson Pharmaceutical Research Raritan, NJ, USA
MalcolmRowland, DSc, PhD
University of Manchester Manchester, United Kingdom
University of California, San Francisco San Francisco, CA, USA
Radojka Savic, PhD
University of California Oakland CA, USA
Virginia D. Schmith, PhD, FCP
GlaxoSmithKline Zebulon, NC, USA
Vikram Sinha, PhD
US Food and Drug Administration Silver Spring,MD, USA
Brian Smith, PhD
Amgen Thousand Oaks, CA, USA
Peter Sorger, PhD
HarvardMedical School Cambridge,MA, USA
Yuichi Sugiyama, PhD
Riken Innovation Center Sugiyama Laboratory Yokohama, Japan
Joel Tarning, PhD
Mahidol-Oxford TropicalMedicine Research Unit Bangkok, Thailand
Nicholas Tatonetti, PhD
Columbia University New York, NY
An Vermeulen, PhD
Janssen Research and Development Beerse, Belgium
Alexander A. Vinks, PharmD, PhD, FCP
University of Cincinnati, College ofMedicine Cincinnati, OH, USA
Overview
CPT: Pharmacometrics & Systems Pharmacology (CPT:PSP) is an official open access journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).
CPT: Pharmacometrics & Systems Pharmacology is a cross-disciplinary journal devoted to publishing advances in quantitative (e.g., modeling and simulation) methods as applied in pharmacology, physiology and therapeutics in humans. The journal welcomes original research articles, reviews and tutorials that bridge the following areas: pharmacometrics, modeling and simulation as applied to the design and evaluation of clinical trials, systems pharmacology modeling, particularly with a mechanistic link to human (patho)physiology, disease modeling, “population” or mixed-effects pharmacokinetics and pharmacodynamics (PKPD) modeling, modeling and simulation to support translational research, physiologically-based pharmacokinetics (PBPK), modelbased meta-analyses of clinical trials, mechanism-based pharmacokinetic-pharmacodynamic modeling, computational pharmacology, bioinformatics, comparative efficacy, effectiveness and cost-effectiveness. Systems pharmacology may involve the application of systems biology approaches to study drug activities, targets and effects. The discipline is often defined with reference to engineering and pharmacological principles as the quantitative analysis of the dynamic interactions between drugs and a biologic system that aims to understand the behavior of the system as a whole. The common focus will be on quantitativemethods that improve our understanding of pharmacology and therapeutics in humans.
Abstracting and Indexing
Embase (Elsevier)
SCOPUS (Elsevier
Society Information
Founded in 1900, the American Society for Clinical Pharmacology and Therapeutics (ASCPT) is a scientific society dedicated to improving the understanding and use of existing drug therapies and developing better and safer treatments for the future. With more than 2,000 professionals whose primary interest is to promote and advance the science of human pharmacology and therapeutics, the society is the largest scientific and professional organization serving the discipline of clinical pharmacology. To learnmore, or to apply for membership, visit: www.ascpt.org
All articles published in this journal are made available under the terms of the Creative Commons Attribution License. Permission is therefore not required for academic or commercial reuse, provided that full attribution is included in the new work.
Disclaimer
The Publisher, Society and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher, Society and Editors, neither does the publication of advertisements constitute any endorsement by the Publisher, Society and Editors of the products advertised.
Publisher
CPT: Pharmacometrics & Systems Pharmacology is published by Wiley Periodicals, Inc., 350 Main Street, Malden, MA 02148; Telephone: 781-388-8200; Fax: 781-388-8210.