Fig. 3.

Verification of putative biomarkers in additional cohort and with orthogonal method. (a) Scatter plots of concentration of LBP, LRG1 and CRP in plasma with small cell lung cancer prior to radiotherapy (SCLC—circle), adenocarcinoma NSCLC (AC—square) or squamous cell carcinoma NSCLC (SqCC—triangle). Levels of the proteins in plasma were assayed by commercial ELISA. (b) Scatter plots of the concentration of LRG1, CRP and LBP in plasma from SqCC patients prior to radiotherapy comparing survival < 14 mo (circle) and > 18 mo (square). (c) Scatter plots of the concentration of LRG1, CRP and LBP in plasma from SqCC patients during radiotherapy comparing survival < 14 mo (circle) and > 18 mo (square). (d) Scatter plots of the concentration of LRG1, CRP and LBP in plasma from AC and SCLC during radiotherapy comparing survival < 14 mo (circle) and > 18 mo (square). Significance was tested using a 2-tailed unpaired Mann Whitney test.