Table 1.
Baseline characteristics of the patients with oral squamous cell carcinoma in three cohorts.
| Characteristic | CD-I cohort (N = 118) |
CD-II cohort (N = 156) |
GZ cohort (N = 94) |
P value⁎ |
|---|---|---|---|---|
| Number (%) | Number (%) | Number (%) | ||
| Age–yr (mean ± sd) | 58.97 ± 13.67 | 58.76 ± 10.62 | 60.39 ± 12.35 | 0.563 |
| < 60 yr | 55 (46.61) | 76 (48.72) | 42 (44.68) | 0.821 |
| ≥ 60 yr | 63 (53.39) | 80 (51.28) | 52 (55.32) | |
| Sex | ||||
| Male | 81 (68.64) | 112 (71.79) | 55 (58.51) | 0.089 |
| Female | 37 (31.36) | 44 (28.21) | 39 (41.49) | |
| Smoking | ||||
| Never | 65 (55.08) | 76 (48.72) | 50 (53.19) | 0.556 |
| Ever | 53 (44.92) | 80 (51.28) | 44 (46.81) | |
| Drinking | ||||
| Never | 62 (52.54) | 76 (48.72) | 55 (58.51) | 0.324 |
| Ever | 56 (47.46) | 80 (51.28) | 39 (41.49) | |
| Differentiation | ||||
| High | 75 (63.56) | 104 (66.67) | 72 (76.60) | 0.144 |
| Moderate | 37 (31.36) | 40 (25.64) | 20 (21.28) | |
| Low | 6 (5.08) | 12 (7.69) | 2 (2.13) | |
| Primary site | ||||
| Ventral tongue/floor of mouth | 50 (42.37) | 71 (45.51) | 54 (57.45) | < 0.001 |
| Buccal mucosa | 18 (15.25) | 27 (17.31) | 10 (10.64) | |
| Gingiva | 15 (12.71) | 23 (14.74) | 25 (26.60) | |
| Othersa | 35 (29.66) | 35 (22.44) | 5 (5.32) | |
| Tumor stage | ||||
| T1 | 36 (30.51) | 34 (21.79) | 19 (20.21) | < 0.001 |
| T2 | 61 (51.69) | 48 (30.77) | 48 (51.06) | |
| T3 | 15 (12.71) | 53 (33.97) | 12 (12.77) | |
| T4 | 6 (5.08) | 21 (13.46) | 15 (15.96) | |
| Nodal stage | ||||
| N0 | 82 (69.49) | 108 (69.23) | 71 (75.53) | 0.522 |
| N1–N3 | 36 (30.51) | 48 (30.77) | 23 (24.47) | |
| Clinical TNM stage | ||||
| I | 28 (23.73) | 29 (18.59) | 15 (15.93) | 0.009 |
| II | 45 (38.14) | 37 (23.72) | 38 (40.43) | |
| III | 24 (20.34) | 57 (36.54) | 20 (21.28) | |
| IV | 21 (17.80) | 33 (21.15) | 21 (22.34) | |
| Surgery type | ||||
| Local | 49 (41.53) | 55 (35.26) | 18 (19.15) | < 0.001 |
| Unilateral neck | 62 (52.54) | 82 (52.56) | 65 (69.15) | |
| Bilateral neck | 6 (5.08) | 4 (2.56) | 6 (5.32) | |
| Other | 1 (0.85) | 15 (9.62) | 5 (5.32) | |
| Radiotherapy | ||||
| Yes | 9 (7.63) | 28 (17.95) | 15 (15.96) | 0.044 |
| No | 109 (92.37) | 128 (82.05) | 79 (84.04) | |
| Chemotherapy | ||||
| Yes | 65 (55.08) | 84 (53.85) | 42 (44.68) | 0.262 |
| No | 53 (44.92) | 72 (46.15) | 52 (55.32) | |
| Radiotherapy or chemotherapy | ||||
| Yes | 67 (56.78) | 93 (59.62) | 49 (52.13) | 0.512 |
| No | 51 (43.22) | 63 (40.38) | 45 (47.87) | |
| PA28γ | ||||
| Low expression | 56 (47.46) | 96 (61.54) | 37 (39.36) | 0.002 |
| High expression | 62 (52.54) | 60 (38.46) | 57 (60.64) |
Abbreviations: CD, Chengdu; GZ, Guangzhou.
⁎
P value of comparison between studies was generated using mixed linear model for continuous variables and chi-square test or Fisher's exact test for categorical variables.
a
Others included hard palate, mandibular and lip mucosa.