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BMJ Open logoLink to BMJ Open
. 2015 Sep 7;5(9):e008597. doi: 10.1136/bmjopen-2015-008597

Biological and steroid use in relationship to quality measures in older patients with inflammatory bowel disease: a US Medicare cohort study

Sophia L Johnson 1, Christie M Bartels 2, Mari Palta 3,4, Carolyn T Thorpe 5,6, Jennifer M Weiss 7, Maureen A Smith 3,8,9
PMCID: PMC4563221  PMID: 26346875

Abstract

Objectives

To examine the frequency and predictors of antitumour necrosis factor (TNF) use, and to describe steroid utilisation among US patients with inflammatory bowel disease (IBD) aged 65 years and older prior to the publication of a new Medicare quality measure calling for the use of anti-TNFs and other steroid-sparing agents.

Design

Retrospective cohort study.

Setting

This study utilised 2006–2009 claims data for a national sample of Medicare beneficiaries.

Participants

Patients with IBD (>1 claim for ICD codes 555.xx, 556.xx) without anti-TNF contraindications, enrolled in Medicare parts A and B ≥12 months and part D ≥6 months were included (n=8502).

Outcome measures

We estimated incidence rate ratios (IRR) and 95% CIs predicting new anti-TNF therapy using multivariable Poisson regression.

Results

This nationally representative study of older patients with IBD estimated that only 3.7% received anti-TNFs. New anti-TNF use (1.4%) was associated with younger age, absence of Medicaid coverage, hospitalisation, and higher preceding use of burst (IRR=2.35, CI 1.59 to 3.47) and maintenance steroids (IRR=2.40, CI 1.05 to 5.48). Among anti-TNF users, we observed high rates of concurrent maintenance steroid use (19%).

Conclusions

Anti-TNF use was very low in this population of older patients with IBD and, importantly, was often combined with maintenance steroid use despite guidelines suggesting reduced needs. Expanding IBD-specific quality measures to include steroid taper plans may cue appropriate maintenance regimens that include anti-TNFs and other steroid sparing agents while reducing protracted concomitant steroid use as intended by current quality measures.

Keywords: GERIATRIC MEDICINE, THERAPEUTICS


Strengths and limitations of this study.

  • A nationally representative sample of US adults aged ≥65 years, with inflammatory bowel disease (IBD).

  • Large cohort (n=8502) allowing the study of drug utilisation in the understudied cohort of older Americans with IBD.

  • Data restrictions were associated with the use of claims data, which required surrogate marker use for IBD severity and limited ascertainment of competing reasons for steroid utilisation.

  • We may have underestimated reported use of self-administered drug therapy in some dual Medicare and Medicaid eligible recipients because we did not have access to Medicaid prescription files. However, 90% of antitumour necrosis factor utilisation would be captured by Medicare claims because facility-administered infliximab was the primary agent used.

Introduction

Inflammatory bowel disease (IBD) affects ∼1.4 million people in the USA and costs $6.3 billion annually,1 2 with 35% of those costs attributed to drug therapy.2 Treatment of IBD aims to achieve remission and to decrease hospitalisations, surgeries and chronic steroid use while improving quality of life.3–6 Reducing maintenance steroid use is important given the complications of chronic steroids and their inability to maintain disease remission.5 7 Tumour necrosis factor (TNF) antagonists (anti-TNFs) reduce both disease activity and steroid requirements in moderate to severe IBD, thus justifying the utilisation of these costly drugs.3 8 9 The Center for Medicare and Medicaid Services (CMS) is the administrator for Medicare, a universal health insurance programme for US citizens ≥65 years old. It provides insurance through a fee for service mechanism for approximately 88% of all beneficiaries, the majority of whom also enrol in the Medicare part D prescription drug benefit.10 11 However, a small proportion of indigent older individuals may also receive Medicaid coverage. Medicaid insurance is administered by individual US state governments according to state and federal government guidelines. Medicaid recipients may receive full Medicaid benefits (which include prescription drug coverage) or may only receive assistance with their Medicare co-insurance payments.12 Given the coverage provided by Medicare, CMS recently adopted IBD-specific quality measures targeting drug therapy optimisation that will impact the care of most US citizens ≥65 years old.13 These measures call for the use of steroid-sparing regimens, highlighting the importance of anti-TNF utilisation.

Despite strong evidence supporting anti-TNFs to maintain steroid-free remission and the rising prevalence of IBD in older patients, there are few studies examining the use of anti-TNF agents in older adults.14 15 The limited data available suggest that these treatments are infrequently used in patients 65 years and older with IBD. One study of a regional hospital system examined drug use in older adults (n=393), and showed higher use of maintenance steroids (n=124) than of anti-TNFs and other steroid-sparing immunomodulators combined (n=37).15 Only 2.6% of older adults were receiving anti-TNFs whereas >30% were receiving steroids. An Italian study found that only 95 of the 3079 (3.1%) anti-TNF recipients in their healthcare system were ≥65 years old.14

The drivers of low anti-TNF utilisation in older patients are likely several, including the exclusion of older adults from anti-TNF clinical trials, potentially less active or symptomatic disease in some older patients, colectomies in some patients with ulcerative colitis and the perceived risk of anti-TNF adverse events occurring with greater frequency in older individuals.16–19

We hypothesised a quality gap whereby older adults infrequently receive anti-TNF treatment. Furthermore, concerns about the risks of potent immunosuppressive agents would exacerbate underuse in the oldest subset of older patients and in those with a lower general state of health. The objectives of the current study are to quantify the prevalence and predictors of anti-TNF use, and to describe steroid use in a nationally representative US sample of patients ≥65 years with IBD, immediately prior to quality measure publication. Our analysis illustrates baseline drug utilisation experience, serves as a reference for future studies of the impact of quality measures and provides a potential roadmap for how these quality measures may need to evolve to optimise the care of older patients with IBD.

Methods

Study design, data source and sample description

We conducted a retrospective cohort study of a random sample of Medicare Fee for Service patients aged ≥65 years, with at least 12 months of parts A and B, and 6 months of part D coverage, during the years 2006–2009. Data were included for up to 6 months prior to coverage by Medicare D. The first 12 months of data are referred to as collected during the ‘baseline year’ and data collected thereafter as being from the ‘follow-up period’.

Claims and administrative data for the Medicare beneficiaries were merged with Census 2010 Summary File 3 (SF3) data (yielding socioeconomic characteristics of household locations). Study participants had a diagnosis of IBD identified by at least two claims for an appropriate International Classification of Diseases, Ninth Edition (ICD-9) code (≥2 claims for either (CD:555.xx) or (UC:556.xx)), according to a case-finding algorithm that confirmed ∼86% of cases on chart review, with a specificity of 79%.20 Participants with contraindications to anti-TNF therapy (advanced congestive heart failure (CHF), malignancy) were excluded (see online supplementary appendix 1). All patients meeting criteria were included in the study, which provided an adequate number of events to evaluate predictors of new anti-TNF use (using the guideline of 1 predictor for every 10 events). Advanced CHF was defined as a diagnosis of CHF and at least one CHF hospitalisation during the baseline year.21 Malignancies were identified using the 2008 Elixhauser criteria, V.3.3 via ICD-9 codes (see online supplementary appendix 1). In accordance with the London position statement on biological therapy, infections were not considered contraindications for the purpose of study exclusion because even patients with latent infections can re-enter the anti-TNF eligible treatment pool following antimicrobial therapy and infection eradication or suppression.22

Outcome variables

The outcome variable was new episodes of anti-TNF utilisation (patients that began a course of anti-TNF therapy during the follow-up period). Prevalent anti-TNF use, defined as use that occurred during the baseline period, was described, but not used as an outcome in regression analysis because explanatory variables were determined while patients were already receiving anti-TNFs. The self-injectable anti-TNF agent (adalimumab) was ascertained from Medicare part D prescription events using the Cerner Multum database (Cerner Multum Incorporated, Denver, Colorado, USA). Infliximab administered through home infusion was found in Medicare part D claims,23 and facility-administered infliximab was identified on inpatient and outpatient facility claims submitted for Healthcare Common Procedure Coding System (HCPCS) J-code 1745.24 The vast majority of patients receiving anti-TNF therapy during the time frame of the study would have the agent administered in a healthcare facility. Since our study utilises claims data, we are assured that a claim was filed because patients came into the facility and received therapy.

Explanatory variables

Predictors of anti-TNF use were determined during the baseline year, and included use of IBD drug classes. The use of oral steroids was determined across the duration of part D coverage, and categorised as a three-level variable according to treatment duration by constructing a patient day data set with patients assigned to having received therapy on a given day based on the ReComp algorithm25 and assuming medication adherence: non-users, short-term users (<180 consecutive days) or maintenance users with ≥180 consecutive days of steroids with no more than a 5-day gap in treatment.13 26 Steroid doses and dosing regimens were not considered in this definition since substantial insult has been demonstrated through cumulative steroid exposures resulting from doses as low as 5 mg daily prednisone equivalent, if used for greater than 3 months.27 Baseline oral steroid use was used in the regression analysis.

IBD severity was accounted for by including indicator variables for IBD-related surgery and >1 endoscopic procedure (see online supplementary appendix 1).28 29 IBD patients with higher colorectal cancer risk should have 1 surveillance endoscopy annually;30 thus, >1 endoscopic procedure during the baseline year was considered to indicate more severe disease.

Several covariates were included to characterise the participant's baseline health status. Specifically, Charlson Comorbidity Index and polypharmacy (≥5 drugs)31 32 were considered as well as variables indicating that there was a hospitalisation and whether a gastroenterologist was seen for an E&M visit appropriate for an IBD encounter.33 Finally, sociodemographic variables identifying urban residential status through rural urban commuting area codes,34 region and socioeconomic status (Medicaid coverage status), were considered.

Statistical analysis

Descriptive statistics are presented for the entire cohort. Prevalent baseline users were excluded from models evaluating the relationship between new episodes of anti-TNF utilisation and patient characteristics. We used Poisson multivariable regression with a log link and robust SEs. As the cohort was dynamic, with varying patient follow-up times, a time-offset was used to adjust for longer observation time, allows participants greater time to initiate drug therapy. Results are presented as incidence rate ratios and 95% CIs. Step-wise model building was employed with age, sex, region, urban status and IBD drug class included in the initial model, and all additional covariates with marginal statistical significance (p<0.1) were retained in the final model.

Statistical analysis was conducted using Stata V.13 (StataCorp, College Station, Texas, USA).

Results

Eighty-two per cent of the full IBD cohort (n=10 362) were without anti-TNF contraindications and, therefore, eligible for study (n=8502; table 1).

Table 1.

Participant baseline characteristics, overall and anti-TNF utilisation status

Full sample (n=8502)
anti-TNF non-users (n=8186)
New episode of anti-TNF users (n=121)*
(n) (%) (n) (%) (n) (%)
Age mean (SD) 76 (8) 76 (8) 73 (6)
Female 6111 72 5891 72 83 69
Caucasian 7708 91 7408 91 118 98†
Region
 Northeast 2104 25 2044 25 29 24
 Southeast 2385 28 2278 28 40 33
 Midwest 2004 24 1922 24 28 23
 Rocky Mountains 239 3 234 3 <11†
 Southwest 802 9 768 9 12 10
 Pacific‡ 968 11 940 12 <11†
Urban/suburban 6426 76 6192 76 87 72
Medicaid coverage 1915 23 1885 23 <11†
Polypharmacy (≥5 drugs) 4920 62 4719 62 72 60
Charlson Index Mean (SD) 1 (2) 1 (2) 1 (2)
Gastroenterologist visit 4392 52 4158 51 76 63
>1 endoscopy 1183 14 1141 14 20 17
IBD surgery 211 3 199 2 <11†
Hospitalisations mean (SD) 1 (1) 1 (1) 1 (1)

*New anti-TNF utilisers initiated therapy after the completion of the baseline period; bivariate analyses is the comparison of new episodes of use to non-use (n=8307); prevalent anti-TNF utilisers were already receiving therapy during the baseline study period (n=195) and were excluded from anti-TNF non-users group (n=8186).

†Cell size is too small and requires suppression as part of the data use agreement.

‡Includes Hawaii, Alaska and Puerto Rico.

IBD, inflammatory bowel disease; TNF, tumour necrosis factor.

All 8502 patients were included in the descriptive analysis. Prevalent anti-TNF users were excluded from the multivariable regression analysis of new anti-TNF utilisation because the analysis was conducted to establish predictors of new anti-TNF use during the follow-up period (n=8307; figure 1).

Figure 1.

Figure 1

Study participation (IBD, inflammatory bowel disease; TNF, tumour necrosis factor). *Case-finding algorithm criteria are met with ≥2 claims for CD:555.xx or UC:556.xx. ***Anti-TNF contraindications are advanced CHF and malignancies as defined in online supplementary appendix 1. ***Prevalent anti-TNF users were already receiving therapy during the baseline period.

Approximately half of all patients and 63% of new anti-TNF users visited a gastroenterologist during the baseline period. Sixty-seven per cent of new anti-TNF users were aged 75 years or younger, 96% were <85 years old and no patient >90 years old received anti-TNF therapy (cohort age range 65–104). Notably, 22% of the full cohort and >40% of new anti-TNF users received a course of steroids during the baseline period (table 2). New anti-TNF recipients also had higher non-biological immunomodulator utilisation rates at baseline than did anti-TNF non-users.

Table 2.

Baseline IBD drug class utilisation by non-anti-TNF baseline users

anti-TNF non-users (n=8186)
New anti-TNF users (n=121)
n Per cent N Per cent p Value*
Systemic corticosteroids (oral)     <0.01
 Short course 1486 18 49 40
 Maintenance therapy 216 3 <11†
Non-biological immunomodulators 378 5 26 22 <0.01
Aminosalicylates 2858 35 73 60 <0.01
Locally administered steroids 97 1 <11† <0.01
Antidiarrhoeals 733 9.0 <11† 0.56

New anti-TNF utilisers initiated therapy after the completion of the baseline period.

Prevalent anti-TNF utilisers were already receiving therapy during the baseline study period (n=195) and were excluded from this analysis.

*Bivariate analyses is the comparison of new episodes of use to non-use (n=8307).

†Cell size is too small and requires suppression as part of the data use agreement.

IBD, inflammatory bowel disease; TNF, tumour necrosis factor.

Overall, 3.7% (n=316) of the cohort received anti-TNF therapy during the course of the study (1.4% new episode use and 2.3% baseline prevalent use; 85.5% infliximab, 10.1% adalimumab, and 4.4% had both infliximab and adalimumab over the study course). The median follow-up period among participants was 2.4 years.

Importantly, 61 of the 316 anti-TNF recipients (19%) received steroid courses lasting greater than 3 months and 10% received a maintenance course that was 6 months or greater while on anti-TNF therapy during the observation period (baseline and follow-up periods combined). Among concomitant anti-TNF and steroid users, 43% had multiple steroid courses spanning >3 months while receiving anti-TNFs.

Multivariable analyses of predictors of anti-TNF utilisation

New anti-TNF users (n=121) were relatively younger than non-users, statistically less likely to be enrolled in Medicaid, and more likely to receive other classes of IBD agents and have a hospitalisation in the baseline year (table 3).

Table 3.

Multivariable rate ratios and 95% CIs predicting new episodes (n-121) of anti-TNF use

IRR* CI
Age (5 years) 0.77 (0.68 to 0.88)
1.04 (0.71 to 1.54)
Medicaid coverage 0.34 (0.18 to 0.66)
Region
 Midwest 1.00 (Reference)
 Northeast 1.17 (0.69 to 1.97)
 Southeast 1.29 (0.80 to 2.07)
 Southwest 1.13 (0.57 to 2.22)
 Rocky Mountains 0.61 (0.14 to 2.63)
 Pacific and HI, AK, PR 0.99 (0.49 to 2.01)
Urban/suburban 0.89 (0.60 to 1.34)
Systemic corticosteroids (oral)
 Short course 2.35 (1.59 to 3.47)
 Maintenance therapy 2.40 (1.05 to 5.48)
Non-biological immunomodulators 3.35 (2.10 to 5.35)
Aminosalicylates 2.03 (1.37 to 3.02)
Locally administered steroids 3.80 (1.90 to 7.61)
Antidiarrhoeals 0.67 (0.33 to 1.33)
Hospitalisations 1.18 (1.01 to 1.38)
Endoscopy (>1) 0.97 (0.43 to 2.23)
IBD-associated surgery 1.09 (0.14 to 8.52)

*Poisson regression with time-to-event as time offset, incident anti-TNF use as dependent variable.

AK, Alaska; HI, Hawaii; IBD, inflammatory bowel disease; IRR, incidence rate ratios; PR, Puerto Rico; TNF, tumour necrosis factor.

Sensitivity analyses

Since some study participants may not have had IBD severity requiring anti-TNF initiation, a sensitivity analysis was conducted restricting the sample to patients who received IBD drugs at baseline (n=4397); findings were similar. Sensitivity analyses were also conducted to evaluate the impact of missing values of urban status (n=60). Excluding this variable from the final model, we compared coefficients with and without individuals with missing values. We found little difference between the two models.

Discussion

Compared with reported rates in younger populations, we found low, 3.7%, utilisation of anti-TNFs in older patients. The rate of utilisation, however, was comparable to rates found in other studies of patients aged ≥65 years with IBD (∼3%).14 15 While older patients may suffer from less severe disease activity,19 we still found anti-TNF utilisation rates in the current study to be low compared with estimates of 11% in the general IBD population.14 15 35 We found the lowest utilisation among the oldest patients, with two-thirds of anti-TNF utilisation reserved for patients aged ≤75 years. Our study had several strengths, including examination of a nationally representative sample of US adults aged 65 years or older with IBD. Despite rising IBD prevalence in this growing population, few studies have examined patients’ anti-TNF utilisation.14 15 Previous studies were conducted in geographically restricted or non-US populations. Using a national Medicare sample, we were able to include 8502 patients with IBD, allowing the identification of anti-TNF use and its predictors, and appraisal of concomitant maintenance steroid use.

The underuse of anti-TNFs in older adults may be due to major anti-TNF clinical trials largely excluding patients aged ≥65 years, resulting in median study population ages of 34–36 years.16 Hence, acceptable safety profiles and outcomes (decreased surgeries and hospitalisations) have not been demonstrated in this subgroup of patients. Moreover, infection and malignancy adverse events may be major concerns for anti-TNF use in older patients.17

Infection and malignancy risks are widely discussed in the anti-TNF literature.36 A systematic review noted that the infection risk exclusively attributable to anti-TNFs is difficult to estimate due to other concomitant immunosuppressive therapies, but reported low overall risk of serious infection in anti-TNF users, particularly with screening and vaccination prior to anti-TNF initiation.36 Steroids, in contrast to anti-TNFs, show significantly higher infection risk.37 Malignancies, particularly lymphomas, might be more common in anti-TNF recipients, though the absolute risk is low and the role of anti-TNFs debatable.36 In summary, advanced age, comorbidities and the lack of research with these drugs in the older population likely contributed to low anti-TNF use, yet older adults remain an important target population for reducing steroid usage through steroid-sparing therapies, including anti-TNFs.

We observed that older adults with dual Medicare and Medicaid coverage had lower anti-TNF utilisation. This finding was not anticipated since Medicare beneficiaries with Medicaid coverage have greatly reduced cost-sharing for medical visits (infused anti-TNF administration) and prescription drug co-payments (self-administered anti-TNFs), and the ability of reduced cost-sharing to increase biological use and drive anti-TNF selection is well documented.38 39 However, infliximab represented 90% of anti-TNF use over the course of this study, and requires the time and expense of commuting to a healthcare facility to receive the drug. Therefore, lower anti-TNF use among individuals who had Medicaid may reflect logistical barriers, patient preferences or other provider and system factors.

A large proportion of patients received concurrent maintenance steroids and anti-TNF therapy during the study, which was surprising. While burst steroids may be used to induce remission during anti-TNF initiation or regimen adjustments, maintenance steroids are not guideline supported. However, there is lack of consensus regarding optimal anti-TNF monitoring, titration, co-therapy use and drug cessation. Anti-TNF non-response (intentional steroid use) or clinical inertia (unintended prolonged steroid use without discontinuation) are both plausible explanations for our finding.40 41 As many as 50% of anti-TNF recipients may become secondary non-responders (lose treatment response following a documented therapeutic response) after 1 year of therapy,40 so it is possible that some patients lost response to treatment. A loss of response should result in anti-TNF dose/interval adjustment, switching anti-TNF agents, anti-TNF discontinuation or the addition of a non-biological immunomodulator to the anti-TNF regimen, but could lead to steroid use.40 Conversely, patients and providers may be conditioned to expect steroid use and overlook steroid tapering.

A policy approach to reduce unintended protracted concomitant steroid and anti-TNF utilisation could include expansion of CMS quality measures to explicitly require documented steroid taper plans for patients on maintenance steroid regimens analogous to the rheumatoid arthritis quality measure calling for annual taper plan documentation (Rheumatoid Arthritis CMS Physician Quality Reporting System (PQRS) Measure #180).42 Broadly speaking, decreasing steroid use may have multiple positive impacts. Patients who are no longer responding to anti-TNF or other steroid-sparing therapy may have their primary therapies more closely monitored and better titrated to treatment response instead of having steroids added to their regimen or steroid therapy prolonged to manage disease flares. Additionally, patients may avoid steroid-associated adverse events that are aggravated when combined with other immunomodulators. While exclusively implementing quality measures or, in this case, expanding quality measures to include steroid taper plans, may not result in substantive behaviour change, there is evidence that quality measure enforcement with an incentive/penalty structure and public reporting of outcomes may positively impact the quality of care received by affected patients.43–45 Both of these strategies, payment adjustments and public reporting, are underway with the CMS measures and PQRS.

In addition to a policy approach, a pragmatic strategy to decrease steroid overuse in this population, engaging patients and primary care clinicians in efforts to understand and promote steroid tapering goals, could also be pursued. Given the fact that only 52% of patients in the current study were seen by a gastroenterologist during the baseline year, it is important that primary care clinicians are empowered to verify the frequency and duration of steroid use with patients, as they may be the provider executing or managing the IBD care plan for long periods of time between gastroenterologist visits. It is also pivotal that patients are fully aware of the safety concerns associated with steroids and report courses of steroid therapy prescribed by all co-managing providers to their primary care clinician, so that they can also advocate for limited steroid use.

Despite strengths of cohort size and representatives, this study had some limitations. A disease-prevalent cohort was used, and disease duration and severity are difficult to ascertain in claims data. Recognising that the majority of patients are diagnosed in the second and third decades of life, we expect that 85–90% of patients had long-standing disease comprising a homogeneous sample with respect to disease duration. With claims data, we did not have access to symptom history, biomarker values or endoscopy results, and we could not assign steroid use to a particular disease state, as it has widespread use among many disease states and older patients are typically comorbid. Given this data restriction, we used surrogate markers (>1 endoscopy and IBD-associated surgeries during the baseline year) to characterise IBD severity and activity, but given the expansive list of steroid indications, we were unable to account for competing uses and acknowledge that some steroid utilisation may be misclassified in this analysis. However, a report derived from National Health and Nutrition Examination Survey (NHANES) III data showed that approximately 1.7% of US citizens aged ≥60 years receive glucocorticoids.46 This rate is far lower than for those observed in the current study. An additional limitation of our database is that it contains claims for older patients and, as such, we cannot make direct comparisons to drug utilisation in younger patients with IBD. Finally, we may have underestimated the use of part D reimbursed agents paid by Medicaid. Nonetheless, a sensitivity analysis excluding patients without IBD drug claims showed similar results to the main analysis. Overall, strengths of this large nationally representative cohort offer a baseline portrayal of anti-TNF and steroid utilisation for future assessments of the impact of the quality measures on prescribing.

In conclusion, our findings point to important potential quality gaps including anti-TNF underuse, aggravated by higher age, and substantial steroid use in older adults during the observed period. Our study highlights the need for a follow-up assessment of drug utilisation following the full adoption of the CMS quality measures, the pragmatic clinical need to reduce steroid overuse in older adults, which may require engaging patients and primary care providers. Moreover, the findings suggest that modifying national quality measures to explicitly call for documented steroid taper plans may be necessary to simultaneously increase the use of steroid-sparing maintenance regimens and reduce concomitant steroid use.

Footnotes

Contributors: SLJ conceived and designed the study, conducted the analyses, data interpretation and manuscript production. SLJ, CMB, MP, CTT, JMW and MAS approved the final submitted manuscript. CMB participated in study design, data interpretation and manuscript writing and editing. MP participated in study and analytic method design, data analysis, data interpretation and manuscript writing. CTT and JMW participated in data interpretation, and manuscript writing and editing. MAS participated in study conception, data interpretation and manuscript production.

Funding: This work was supported by the Agency for Healthcare Research and Quality [grant number 1 F32 HS022786-01].

Competing interests: None declared.

Ethics approval: University of Wisconsin Institutional Review Board.

Provenance and peer review: Not commissioned; externally peer reviewed.

Data sharing statement: No additional data are available.

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