Table 2.
Genome-wide association of single SNPs with susceptibility to salivary gland carcinoma
| Location (Base Pair) | MAFa | Non-Hispanic Whites | Hispanics | Meta-analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chromosome | Candidate Gene | Allele | Functional Annotation | Outcome Annotation | Case | Control | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | P heterogeneity | |
| exm2258812 | 8 | 27321189 | CHRNA2 | G>A | Synonymous | - | 0.11 | 0.015 | 8.55 (4.53-16.13) |
3.6 × 10−11 | 15.72 (1.73-142.7) |
1.4 × 10−2 | 8.95 (4.86-16.48) |
1.9 × 10−12 | 0.61 |
| exm1194739 | 15 | 102346271 | OR4F15 | G>A | A117T | Benign | 0.13 | 0.029 | 5.26 (3.13-8.83) |
3.5 × 10−10 | - | - | - | - | - |
| exm1519918 | 20 | 2464112 | ZNF343 | A>G | R499G | Benign | 0.14 | 0.04 | 3.28 (2.12-5.07) |
9.1 × 10−8 | 2.91 (0.77-10.98) |
0.12 | 3.24 (2.14-4.91) |
2.6 × 10−8 | 0.87 |
| exm1057993 | 13 | 25074490 | PARP4 | G>A | S122N | Benign | 0.36 | 0.20 | 2.00 (1.54-2.59) |
1.7 × 10−7 | 3.65 (1.46-9.14) |
5.6 × 10−3 | 2.09 (1.63-2.68) |
7.0 × 10−9 | 0.21 |
| exm2265979 | 5 | 95234350 | ELL2 | A>G | Synonymous | - | 0.40 | 0.29 | 1.91 (1.49-2.44) |
2.6 × 10−7 | 1.54 (0.80-2.99) |
0.20 | 1.86 (1.48-2.34) |
1.3 × 10−7 | 0.55 |
a
Minor allele frequency in non-Hispanic whites.