There are errors in the Results section of this article. In fifth sentence of the “Identification of G6PD mutations” subsection, 9.7% should be 89.7%. The correct sentence is: Of these 87 cases, the Mahidol 487G>A type was the most predominant, occurring in 89.7% (78/87) of the subjects.
In the eighth sentence of the same subsection, 58.0% should be 48%. The correct sentence is: In addition, the silent mutation 1311C>T and the intron 11 mutation IVS11nt93T>C co-occurred in 48% (95/198) of the tested individuals (Table 2).
Table 2. Prevalence [n (%)] of G6PD variants in 198 unrelated G6PD-deficient participants # .
| Mutations | Amino Acid Substitution | Total (n = 198) | Female (n = 147) | Male (n = 51) | P * | |
|---|---|---|---|---|---|---|
| Homozygous | Heterozygous | |||||
| Nonsynonymous mutations | ||||||
| Chinese 4 392G>T | G131V | 1 (0.5%) | 0 | 1 (0.7%) | 0 | |
| Mahidol 487G>A | G163S | 76 (38.4%) | 5 (3.4%) | 52 (35.4%) | 19 (37.3%) | 0.870 |
| Viangchan 871G>A | V291M | 1 (0.5%) | 0 | 1 (0.7%) | 0 | |
| Canton 1376G>T | R459L | 1 (0.5%) | 0 | 1 (0.7%) | 0 | |
| Kaiping 1388G>A | R463H | 6 (3.0%) | 1 (0.7%) | 3 (2.0%) | 2 (3.9%) | 0.000 |
| Mahidol/Viangchan | G163S/V291M | 1 (0.5%) | 0 | 1 (0.7%) | 0 | |
| Mahidol/Kaiping | G163S/R463H | 1 (0.5%) | 0 | 1 (0.7%) | 0 | |
| Synonymous mutations | ||||||
| 1311C >T/93 T>C** | Silent mutations | 95 (48.0%) | 9 (6.1%) | 74 (50.3%) | 12 (23.5%) | 0.000 |
| Unknown | 42 (21.2%) | 24 (16.3%) | 18 (35.3%) | |||
# The mutations Gaohe 95 A >G (H32R), Coimbra 592 C >T (R198C), Chinese 5 1024C >T (L342F), and Union 1360 C>T (R454C) were genotyped and not found in this study population.
*P value shows the differences in the prevalence of major G6PD deficiency variants between males and females compared using the Fisher’s exact test (two-tailed).
** 24 and 2 of these double silent mutations co-occurred in females heterozygous for the Mahidol and Kaiping mutations, respectively.
In addition, there is an error in Table 2: The value 18(35.3%) should not appear in the “Heterozygous” column but in the “Male (n = 51)” column. Please see the correct Table 2 here.
Reference
- 1. Li Q, Yang F, Liu R, Luo L, Yang Y, Zhang L, et al. (2015) Prevalence and Molecular Characterization of Glucose-6-Phosphate Dehydrogenase Deficiency at the China-Myanmar Border. PLoS ONE 10(7): e0134593 doi:10.1371/journal.pone.0134593 [DOI] [PMC free article] [PubMed] [Google Scholar]