Table 1. Nups Associated with NPC Pathways.
| NLS/NES Motif sequence | Required Nups1 | Karyopherin1 | |
|---|---|---|---|
| Classical import pathway. NLS is from the SV40 large T- antigen protein |
Nup62 | Nup214 | importin α/β |
| Nup98 | Nup358 | ||
| Nup153 | |||
|
| |||
| M9-mediated import pathway. NLS is from the M9 domain of mRNA binding protein hnRNPA1 |
Nup62 | transportin 1 | |
| Nup98 | |||
| Nup153 | |||
|
| |||
| RS-mediated import pathway. NLS is from the RS domain of splicing factor 2, an SR (Arg/Ser-rich) protein. |
Nup98 | transportin 3 | |
| Nup153 | |||
|
| |||
| Leucine-rich NES-mediated export pathway. NES is from the protein kinase A inhibitor (PKI) |
Nup62 | Nup214 | Crm1 |
| Nup98 | Nup358 | ||
| Nup153 | |||