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Effect of anti-miR-21 treatment on arterial blood pressures in mice. Blood pressure and heart rate were measured in C57BL/6J mice on AIN-76A diet containing 0.4% NaCl or 4% NaCl and receiving intraperitoneal injections of either scrambled LNA anti-miR or anti-miR-21 (10 mg/kg body weight) on days 3 and 12 as indicated. Blood pressure and heart rate were averaged over each 24 hour period (day) throughout the 16 day protocol. N=4/group, * P<0.05 vs scrambled anti-miR.
