Figure 1.

(A) Schematic of the MHIFU device and MHIFU-mediated TSL release. Device architecture shows the SPUDT with curved electrodes to generate the focused SAW on the LiNbO3 piezoelectric wafer. The MHIFU is coupled to the PDMS cavity. Inset: the encapsulated drug is released from TSL due to the mechanical and thermal effects of MHIFU. The drug is then internalized by 4T1 cells cultured in PDMS cavity. (B) Optical imaging of MHIFU device. Inset: The finger pairs of the SPUDT on the substrate. The MHIFU was fabricated by deposition of circular electrodes on a 1 mm thickness 128° Y-rotated, X-propagating LiNbO3 substrate. In all experiments, only one SPUDT was excited to generate the MHIFU.