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Model for the promotion of cancer metastasis by loss of Fbxw7 in the host environment. Excessive signaling by Notch1 due to the impairment of its degradation caused by Fbxw7 ablation gives rise to increased production of CCL2 by bone marrow-derived stromal cells (BMSCs). The consequent recruitment of Mo-MDSCs and macrophages facilitates metastatic tumor growth.
