Table 1.
Main inhibitory and activating γδ T cell receptors and their ligands
| Receptor on γδ T cells | Ligand(s) | ||
|---|---|---|---|
| Activating receptors | TCR | – | Both MHC-related and non-related molecules |
| CD28 | – | CD80/CD86 | |
| CD27 | – | CD70 | |
| LFA-1 | – | ICAM-1 | |
| CD2 | – | LFA-3 | |
| CD6 | – | CD166 | |
| CD30 | – | CD30L | |
| NKG2C | – | HLA-E | |
| NKG2D | – | MICA/BULBP1-6 | |
| CD16 | – | Fc portions IgG1, IgG3 | |
| DNAM-1 | – | Nectin-like-5, Nectin-2 | |
| NKp30 | – | B7-H6, BAT3 | |
| NKp44 | – | ? | |
| NKp46 | – | ? | |
| Inhibitory receptors | PD-1 | – | PD-L1 |
| ILT2 | – | HLA-A | |
| KIR2D | – | HLA-C | |
| NKG2A | – | HLA-E | |
| KLRG1 | – | Classical cadherins (E-,N-, R-) | |
| BTLA | – | HVEM, B7H4 |
Abbreviations: BAT3, HLA-B associated transcript 3; BTLA, B- and T-lymphocyte attenuator; CD, cluster of differentiation; DNAM-1, DNAX accessory molecule-1; HLA, human leukocyte antigen; Ig, Immunoglobulin; HVEM, herpesvirus entry mediator; ICAM-1, intercellular adhesion molecule 1; ILT, immunoglobulin-like transcript; KIR, killer-cell immunoglobulin-like receptor; KLRG1, killer cell lectin-like receptor subfamily G member 1; LFA, lymphocyte function-associated antigen; MHC, major histocompatibility complex; MIC, major histocompatibility complex class I-related chain; NKG, natural killer group; NKp, natural killer cell px-related protein; PD-1, programmed cell death protein 1; TCR, T cell receptor; ULBP, UL16-binding protein.