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. 1988 Sep;7(9):2795–2799. doi: 10.1002/j.1460-2075.1988.tb03134.x

Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients.

D S Anson 1, D J Blake 1, P R Winship 1, D Birnbaum 1, G G Brownlee 1
PMCID: PMC457070  PMID: 2846283

Abstract

The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3' of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.

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Selected References

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